Baseline optical coherence tomography angiography biomarkers predict visual outcomes in treatment-naïve neovascular age-related macular degeneration patients.

Autor: Faghihi S; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Faghihi H; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Bazvand F; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Mehrabi Bahar M; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Torkashvand A; Noor Eye Institute, Tehran, Iran., Husein Ahmed A; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Rahimi M; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Akbarzadeh A; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Asadi Khameneh E; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran. asadi_tums@yahoo.com., Khalili Pour E; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran., Riazi-Esfahani H; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Sq, Tehran, 1336616351, Iran.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 18; Vol. 14 (1), pp. 24528. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1038/s41598-024-75530-x
Abstrakt: This retrospective study aimed to assess different macular neovascular network characteristics in relation to changes in best corrected visual acuity (BCVA) over 3 and 12 months following treatment. Using optical coherence tomography angiography, we reviewed the medical records of 46 treatment-naïve patients with neovascular age-related macular degeneration (nAMD) who received intravitreal aflibercept injections. The change in BCVA from baseline to 3 months and 12 months after treatment was recorded. The mean vessels percentage area, junctions density, lacunarity, and fractal dimension were significantly correlated with the change of BCVA from baseline to month 3 (P = 0.003, 0.046, 0.007, and 0.005 respectively). Fractal dimension and vessels percentage area were correlated with the change of BCVA from baseline to month 12 (P = 0.023 and 0.023 respectively). The findings suggest that baseline characteristics of macular neovascular complexes may serve as predictors for BCVA changes following treatment with aflibercept in nAMD patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
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