Polymer powerhouse: Methyl methacrylate - A breakthrough blend for superior adhesion to gingiva.

Autor: Sanchez Armengol E; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria., Sánchez Soler LA; Faculty of Medicine and Health Sciences, Department of Odontostomatology, University of Barcelona, Barcelona, Spain., Valverde Offermann N; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria., Laffleur F; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria. Electronic address: Flavia.Laffleur@uibk.ac.at.
Jazyk: angličtina
Zdroj: Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2024 Dec; Vol. 40 (12), pp. 2101-2113. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1016/j.dental.2024.10.002
Abstrakt: The goal of this study was to develop a new poly(methyl methacrylate) (PMMA)-based conjugate with enhanced mucoadhesive features for gingiva. Five MMA-based conjugates with varying amounts of hydroxyethyl maleimide (HEM) and poly(ethylene glycol) (PEG) were synthesized and characterized using infrared spectroscopy and proton nuclear magnetic resonance. Quantification of attached HEM and PEG was performed using assay kits and established protocols. Mucoadhesiveness was tested through rheological measurements, retention time, and tensile strength studies. Results showed successful unification of MMA with HEM and PEG, with varying degrees of modification and no toxic effects. Dynamic viscosity was enhanced up to 13-fold for MMA-100Mal, decreasing incrementally for MMA-75Mal, MMA-50Mal, MMA-25Mal, and MMA-0Mal. Retention time improved up to 120-fold for MMA-100Mal, decreasing to 37.5-fold for MMA-0Mal. Mucoadhesiveness followed the order: MMA-100Mal > MMA-75Mal > MMA-50Mal > MMA-25Mal > MMA-0Mal. In conclusion, the novel modification of MMA with increased mucoadhesive features to buccal gingiva suggests its potential as a long-term total denture base material, paving the way for more patient-friendly prostheses.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: