Ongoing Clinical Trials for Polycystic Ovarian Syndrome (PCOS) Afflicted Infertility in Women: A Narrative Review.

Autor:	Shukla R; Department of Clinical Research, Sharda School of Allied Health Science, Sharda University Greater Noida, 201310, India., Chadha M; Department of Nutrition and Dietetics, Sharda School of Allied Health Science, Sharda University, Greater Noida, 201310, India., Adya A; Department of Nutrition and Dietetics, Sharda School of Allied Health Science, Sharda University, Greater Noida, 201310, India., Yadav A; Department of Clinical Research, Sharda School of Allied Health Science, Sharda University Greater Noida, 201310, India., Singh N; Department of Clinical Research, Sharda School of Allied Health Science, Sharda University Greater Noida, 201310, India., Chauhan RS; Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh-226014, India., Ahmad A; Department of Public Health, Dr. Giri Lal Gupta Institute of Public Health, University of Lucknow, Lucknow, Uttar Pradesh-226007, India., Tiwari RK; Department of Clinical Research, Sharda School of Allied Health Science, Sharda University Greater Noida, 201310, India.
Jazyk:	angličtina
Zdroj:	Reviews on recent clinical trials [Rev Recent Clin Trials] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.
DOI:	10.2174/0115748871325070241008101355
Abstrakt:	Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder that affects women of reproductive age. PCOS is further correlated with infertility, menstrual dysfunction, and hyperandrogenism. Despite the advanced understanding of reproductive biology, the exact causes of PCOS remain ambiguous. Nevertheless, several factors are believed to contribute to the development of PCOS, including insulin resistance, hyperinsulinemia, obesity, and genetic predispositions. The diagnosis of PCOS is complicated by its phenotypic heterogeneity, which manifests differently in different individuals. Presently, the therapeutic management of PCOS-afflicted infertility depends upon proper pharmaceutical-based therapies aimed at treating underlying symptoms, such as the use of clomiphene citrate, metformin, ovulation-inducing agents, anti-androgens, exogenous gonadotropin administration, laparoscopic ovarian drilling, and in vitro fertilization. The present review focuses on narrating present therapeutic interventions along with lifestyle modifications in PCOS. Furthermore, it focuses on the ongoing clinical trials of various chemotherapeutics to counter PCOS-induced infertility among women. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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