Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor.

Autor:	Brunner E; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria., Kunze L; Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria., Laidlaw V; Johannes Kepler University Linz, Industrial Mathematics Institute, Altenbergerstraße 69, A-4040 Linz, Austria., Jodlbauer D; Johann Radon Institute for Computational and Applied Mathematics, Altenbergerstraße 69, A-4040 Linz, Austria., Drexler W; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria., Ramlau R; Johannes Kepler University Linz, Industrial Mathematics Institute, Altenbergerstraße 69, A-4040 Linz, Austria., Pollreisz A; Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria., Pircher M; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2024 Sep 30; Vol. 15 (10), pp. 6098-6116. Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024).
DOI:	10.1364/BOE.533451
Abstrakt:	We present improvements on the adaptive optics (AO) correction method using a pyramid wavefront sensor (P-WFS) and introduce a novel approach for closed-loop focus shifting in retinal imaging. The method's efficacy is validated through in vivo adaptive optics optical coherence tomography (AO-OCT) imaging in both, healthy individuals and patients with diabetic retinopathy. In both study groups, a stable focusing on the anterior retinal layers is achieved. We further report on an improvement in AO loop speed that can be used to expand the imaging area of AO-OCT in the slow scanning direction, largely independent of the eye's isoplanatic patch. Our representative AO-OCT data reveal microstructural details of the neurosensory retina such as vessel walls and microglia cells that are visualized in single volume data and over an extended field of view. The excellent performance of the P-WFS based AO-OCT imaging in patients suggests good clinical applicability of this technology. Competing Interests: The named authors have no conflict of interest, financial or otherwise. (© 2024 The Author(s).)
Databáze:	MEDLINE
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