Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain's drainage in healthy male mice.

Autor:	Blokhina I; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Terskov A; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Evsiukova A; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Dubrovsky A; Institute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia., Adushkina V; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Zlatogorskaya D; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Dmitrenko A; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Tuzhilkin M; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Manzhaeva M; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Krupnova V; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia., Ilyukov E; Institute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia., Myagkov D; Institute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia., Tuktarov D; Institute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia., Popov S; Institute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia., Tzoy M; Institute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia., Shirokov A; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.; Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Prospekt Entuziastov 13, Saratov 410049, Russia., Fedosov I; Institute of Physics, Saratov State University Astrakhanskaya Str. 83, 410012 Saratov, Russia., Semyachkina-Glushkovskaya O; Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2024 Sep 26; Vol. 15 (10), pp. 6063-6072. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).
DOI:	10.1364/BOE.527892
Abstrakt:	Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA. Competing Interests: The authors declare no conflict of interest. (© 2024 Optica Publishing Group.)
Databáze:	MEDLINE
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