Associations of DNA-methylation measures of biological aging with social disparities in child and adolescent mental health.

Autor:	Raffington L; Max Planck Research Group Biosocial - Biology, Social Disparities, and Development; Max Planck Institute for Human Development; Lentzeallee 94, 14195 Berlin, Germany.; Department of Psychology, The University of Texas at Austin, Austin, TX, USA.; Population Research Center, The University of Texas at Austin, Austin, TX, USA., Tanksley PT; Department of Psychology, The University of Texas at Austin, Austin, TX, USA.; Population Research Center, The University of Texas at Austin, Austin, TX, USA., Vinnik L; Department of Psychology, The University of Texas at Austin, Austin, TX, USA., Sabhlok A; Department of Psychology, The University of Texas at Austin, Austin, TX, USA., Patterson MW; Department of Psychiatry, University of Colorado, Denver - Anschutz Medical Campus, Aurora, CO, USA., Mallard T; Department of Psychology, The University of Texas at Austin, Austin, TX, USA., Malanchini M; Department of Biological and Experimental Psychology, Queen Mary University of London, UK., Ayorech Z; PROMENTA Research Center, Department of Psychology, University of Oslo, Norway., Tucker-Drob EM; Department of Psychology, The University of Texas at Austin, Austin, TX, USA.; Population Research Center, The University of Texas at Austin, Austin, TX, USA., Harden KP; Department of Psychology, The University of Texas at Austin, Austin, TX, USA.; Population Research Center, The University of Texas at Austin, Austin, TX, USA.
Jazyk:	angličtina
Zdroj:	Clinical psychological science : a journal of the Association for Psychological Science [Clin Psychol Sci] 2024 Jul; Vol. 12 (4), pp. 551-562. Date of Electronic Publication: 2023 Aug 07.
DOI:	10.1177/21677026231186802
Abstrakt:	Children who experience environmental adversities are at increased risk of both internalizing and externalizing disorders. Epigenetic mechanisms may regulate the influence of environmental adversities on mental health. We examined the hypothesis that salivary DNA-methylation patterns of pace of biological aging (DunedinPoAm) and inflammation (DNAm-CRP) are socially stratified and associated with mental health in 1,183 children (609 female, age M=13.6y) from the Texas Twin Project. Analyses were preregistered. Participants' DNA-methylation algorithms and psychiatric symptoms differed by socioeconomic contexts and race/ethnicity. Children with more parent-reported internalizing symptoms had higher DunedinPoAm and DNAm-CRP scores, and children with more aggression problems had higher DNAm-CRP. DunedinPoAm partially mediated advantage of White racial identity on internalizing. Similarly, DNAm-CRP partially mediated advantage of higher family socioeconomic contexts and, in a separate model, White racial identity on reduced internalizing symptoms. Children's epigenetic measures of pace of biological aging and inflammation are associated with social inequalities and mental health. Competing Interests: Conflicts of interest: The author(s) declare that there were no conflicts of interest with respect to the authorship or the publication of this article.
Databáze:	MEDLINE
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