Findings and methodologies in oral phageome research: a systematic review.

Autor:	Chen X; Shenzhen Children's Hospital, China Medical University (CMU), Shenzhen, China.; Department of Stomatology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China., Zou T; Shenzhen Clinical College of Stomatology, School of Stomatology, Southern Medical University, Shenzhen, Guangdong, China.; Central Laboratory, Shenzhen Stomatology Hospital (Pingshan) of Southern Medical University, Shenzhen, China., Ding G; Shenzhen Children's Hospital, China Medical University (CMU), Shenzhen, China.; Department of Stomatology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China., Jiang S; Shenzhen Clinical College of Stomatology, School of Stomatology, Southern Medical University, Shenzhen, Guangdong, China.; Department of Periodontology, Shenzhen Stomatology Hospital (Pingshan) of Southern Medical University, Shenzhen, China.
Jazyk:	angličtina
Zdroj:	Journal of oral microbiology [J Oral Microbiol] 2024 Oct 16; Vol. 16 (1), pp. 2417099. Date of Electronic Publication: 2024 Oct 16 (Print Publication: 2024).
DOI:	10.1080/20002297.2024.2417099
Abstrakt:	Background: The oral microbiome serves as both an indicator and a mediator of oral health. Evidence indicates that bacteriophages (phages) are widely present in the oral microbiome and exhibit diverse classifications and interactions with human cells and other microbes. These phages constitute the oral phageome, which potentially exerts significant yet unexplored effects on the interplay between oral and general health. Methods: Three databases (PubMed/MEDLINE, Embase and Scopus) were searched for metagenomic analyses that investigated the oral phageome. Eligible studies were synthesized based on their methodological approaches and findings. Results: A total of 14 articles were included in this systematic review. Among the 14 articles included, there were six studies that discussed disease-related alterations, along with a discursive examination of additional variables such as sampling niches, external interventions and methodologies. The phages that infect Streptococcus Actinomyces Haemophilus , and Veillonella have been discovered to be associated with chronic periodontitis, caries, and pancreatic ductal carcinoma. Conclusions: This systematic review focuses on findings and methodologies in oral phageome studies, which were conducted using highly heterogeneous methodologies that explored the oral phageome in multiple directions while placing constraints on quantitative statistics. Combining different kinds of sample types, utilizing the characteristics of different methods, involving both DNA and RNA phages, and differentiating lysogenic and lytic phages should be the distinction of further studies. Competing Interests: No potential conflict of interest was reported by the author(s). (© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Databáze:	MEDLINE
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