Active fraction of ground cherry ( Physalis angulata L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice.

Autor:	Ocampo Y; Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia., Caro D; Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia.; Dentistry Program, Universidad del Sinú-Elías Bechara Zainúm-Seccional Cartagena, Cartagena 130014, Colombia., Rivera D; Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia., Castro J; Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia.; Faculty of Chemistry and Pharmacy, Universidad del Atlántico, Barranquilla 081007, Colombia., Pájaro I; Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia.; Faculty of Chemistry and Pharmacy, Universidad del Atlántico, Barranquilla 081007, Colombia., Salas R; Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia., Franco L; Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia.
Jazyk:	angličtina
Zdroj:	Biomedical reports [Biomed Rep] 2024 Oct 10; Vol. 21 (6), pp. 188. Date of Electronic Publication: 2024 Oct 10 (Print Publication: 2024).
DOI:	10.3892/br.2024.1876
Abstrakt:	Physalis angulata L., commonly known as wild tomato or ground cherry, is widely used in tropical and subtropical areas to treat health disorders including inflammation, hepatitis, dermatitis, cancer and diabetes. In Colombia, anti-cancer and anti-inflammatory activity are the most common ethnopharmacological applications of P. angulata calyces. P. angulata dichloromethane fraction (PADF) has significant anti-inflammatory activity. The present study assessed the pharmacological effect of PADF on colorectal cancer (CRC) using cancer and normal human cells and an azoxymethane (AOM)/dextran sulfate sodium (DSS) murine model. MTT and clonogenic assay, cell cycle and apoptosis analysis and mitochondrial membrane potential measurement were employed to evaluate in vitro activity of PADF. PADF selectively induced a cytotoxic effect against CRC cells via apoptosis and G2/M arrest. In the AOM/DSS model, treatment with PADF diminished tumor number and size, affected area and expression of proliferating cell nuclear antigen and promoted colon tissue repair. These effects might be related to the increased expression of p38 pro-apoptotic protein in addition to anti-inflammatory activity of PADF demonstrated by decreased levels of TNF-α, IL-6, and IL-1β. PADF may serve as a potential treatment for CRC. Further investigation is warranted to identify the bioactive components in PADF. Competing Interests: The authors declare that they have no competing interests. (Copyright: © 2024 Ocampo et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu