Use of transient elastography for hepatic steatosis and fibrosis evaluation in patients with subclinical hypothyroidism.

Autor:	Santos MTAN; Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Endocrinologia Rio de JaneiroRJ Brasil Divisão de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Villela-Nogueira CA; Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Hepatologia Rio de JaneiroRJ Brasil Divisão de Hepatologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Leite NC; Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Hepatologia Rio de JaneiroRJ Brasil Divisão de Hepatologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Teixeira PFDS; Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Endocrinologia Rio de JaneiroRJ Brasil Divisão de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., de Souza MVL; Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Divisão de Endocrinologia Rio de JaneiroRJ Brasil Divisão de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Jazyk:	angličtina
Zdroj:	Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2024 Aug 09; Vol. 68, pp. e230477. Date of Electronic Publication: 2024 Aug 09 (Print Publication: 2024).
DOI:	10.20945/2359-4292-2023-0477
Abstrakt:	Objective: To evaluate the association between subclinical hypothyroidism and hepatic steatosis and fibrosis using the noninvasive diagnostic methods transient hepatic elastography (TE) and controlled attenuation parameter (CAP) in patients with subclinical hypothyroidism. Subjects and Methods: This was a cross-sectional study including women with confirmed spontaneous subclinical hypothyroidism and an age- and body mass index (BMI)-matched control group without thyroid disease or circulating antithyroperoxidase (anti-TPO) antibodies. Exclusion criteria were age > 65 years, thyroid-stimulating hormone (TSH) > 10.0 mIUI/L, BMI ≥ 35 kg/m 2 , diabetes, or other chronic liver diseases. Liver stiffness was classified according to TE values (in kPa) and ranged from absence of fibrosis (F0) to advanced fibrosis (F3). Hepatic steatosis was classified according to CAP values (in dB/m) and ranged from low-grade (S1) to advanced (S3) steatosis. Results: Of 68 women enrolled, 27 were included in the subclinical hypothyroidism group and 41 in the control group. Advanced steatosis (S3) was more frequent in the subclinical hypothyroidism group (25.9% versus 7.3%, respectively, p = 0.034). Circulating anti-TPO was an independent factor associated with advanced steatosis (odds ratio 9.5, 95% confidence interval 1.3-68.3). In multiple linear regression analysis, TE values (which evaluated fibrosis) correlated negatively with free thyroxine levels. Conclusion: The results of this study strengthen the hypothesis that hepatic steatosis is associated with autoimmune (positive anti-TPO) subclinical hypothyroidism, independently from BMI. However, subclinical hypothyroidism alone does not appear to be associated with a significantly increased risk of hepatic fibrosis. Competing Interests: Disclosure: no potential conflict of interest relevant to this article was reported.
Databáze:	MEDLINE
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