Plasma protein binding of arsenic species in acute promyelocytic leukemia patients and their relationships with hepatic and renal function.
| Autor: | Gao C; Department of Pharmacy, The First Affiliated Hospital, Harbin Medical University, Harbin, China., Duan R; Department of Pharmacy, The First Affiliated Hospital, Harbin Medical University, Harbin, China., Tian S; Department of Pharmacy, The First Affiliated Hospital, Harbin Medical University, Harbin, China., Pang C; Department of Pharmacy, The First Affiliated Hospital, Harbin Medical University, Harbin, China., Zhang H; Department of Pharmacy, The First Affiliated Hospital, Harbin Medical University, Harbin, China., Yang H; Department of Pharmacy, The First Affiliated Hospital, Harbin Medical University, Harbin, China., Hai X; Department of Pharmacy, The First Affiliated Hospital, Harbin Medical University, Harbin, China. |
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| Jazyk: | angličtina |
| Zdroj: | Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2024 Nov; Vol. 17 (11), pp. 1063-1069. Date of Electronic Publication: 2024 Oct 18. |
| DOI: | 10.1080/17512433.2024.2417666 |
| Abstrakt: | Objectives: Percentage protein binding (%PB) of arsenic species in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide remains unclear. It can be different depending on the status of hepatic or renal function. Methods: This study obtained steady-state blood samples from normal APL patients and those with hepatic or renal impairment. %PB of inorganic arsenic (iAs), monomethylarsonic acid (MMA V ), and dimethylarsinic acid (DMA V ) was determined by analyzing free and total plasma concentrations using ultrafiltration method by HPLC-HG-AFS. Results: There is a linear relationship between free and total plasma concentrations for iAs (r 2 = 0.952), MMA V (r 2 = 0.603), and DMA V (r 2 = 0.945). For patients with normal hepatic and renal function, mean %PB was as follows: iAs at 26.7 ± 14.3%, MMA V at 53.3 ± 11.9%, and DMA V at 24.7 ± 7.8%. %PB decreased in patients with renal impairment, with MMA V and DMA V showing statistically significant differences ( p < 0.05 for MMA V , p < 0.01 for DMA V ). No significant differences in %PB between normal and hepatic impairment group were observed. Conclusion: Free arsenic species fraction can be estimated by total concentration. DMA V and iAs present low %PB, while MMA V exhibits a relatively high %PB in plasma. Level of %PB is more likely to be affected by renal function and age. |
| Databáze: | MEDLINE |
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