Brain encoding during perceived control as a prospective predictor of improvement in quality of life.

Autor:	Dan R; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA., Brown AR; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA., Hutson L; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA., Belleau EL; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA., Esfand SM; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA., Ruberto V; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA., Johns E; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA., Null KE; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA., Du F; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.; McLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA., Pizzagalli DA; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.; McLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA.
Jazyk:	angličtina
Zdroj:	Social cognitive and affective neuroscience [Soc Cogn Affect Neurosci] 2024 Nov 12; Vol. 19 (1).
DOI:	10.1093/scan/nsae075
Abstrakt:	Perceived control is strongly related to mental health and well-being. Specifically, lack of perceived control has been associated with learned helplessness and stress-related disorders, such as depression and anxiety. However, it is unknown whether brain activation to control and its protective effect against stress can predict changes in quality of life. To address this gap, we examined the neural underpinning of controllability in healthy females (N = 40) performing the Value of Control task in an functional magnetic resonance imaging scanner. Quality of life and perceived stress were assessed at baseline and 6-month follow-up. Increased brain activation for control was found within the putamen, insula, thalamus, mid-cingulate, dorsolateral prefrontal cortex, motor cortex, and cerebellum. In contrast, increased brain activation for lack of control was found within the posterior cingulate and prefrontal cortices. In an exploratory analysis, an elastic-net algorithm was used to identify brain predictors of quality of life 6 months later. The right putamen's activation to control was selected as the best prospective predictor of improvement in life enjoyment and satisfaction and this association was mediated by changes in perceived stress. Our findings suggest that neural responsiveness to control may have utility as a potential marker of quality of life and resilience to adversity. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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