High altitude impact on serum bicarbonate in healthy Mexican children: concerning the overdiagnosis of renal tubular acidosis.
| Autor: | Negrete-Pedraza FH; Pediatric Nephrology Unit, Regional High-Specialty Hospital of Ixtapaluca, Ixtapaluca, Mexico. helinegrete@yahoo.com., Garcia-Nieto V; Pediatric Nephrology Unit, University Hospital of Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain., Castro-Fuentes CA; Research Unit, Regional High-Specialty Hospital of Ixtapaluca, Ixtapaluca, Mexico., Valencia-Ledezma OE; Research Unit, Regional High-Specialty Hospital of Ixtapaluca, Ixtapaluca, Mexico. |
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| Jazyk: | angličtina |
| Zdroj: | BMC nephrology [BMC Nephrol] 2024 Oct 17; Vol. 25 (1), pp. 359. Date of Electronic Publication: 2024 Oct 17. |
| DOI: | 10.1186/s12882-024-03779-5 |
| Abstrakt: | Background: Altitude influences bicarbonate levels, it is a variable that is hardly considered in diagnosing Renal Tubular Acidosis (RTA), so it should be a factor to consider when diagnosing this pathology, especially at 2250 mts over the sea level as it is the case of Mexico City. RTA is most often misdiagnosed. Regarding of this, the present study established reference limits for bicarbonate levels in healthy children without pathologies associated with alterations in the acid-base balance in Mexico City and it´s metropolitan area. Methods: A total of 267 healthy pediatric patients were included, within normal estimated glomerular filtration rate (eGFR), and without any associated pathology of any alteration in the acid-base balance. Results: Compared to older children, children younger than two years of age showed statistically higher levels of calcemia and cystatin C. On the other hand, this same group showed lower values of creatininemia, pCO Conclusions: In the study population, an effect of altitude on blood levels of pCO (© 2024. The Author(s).) |
| Databáze: | MEDLINE |
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