Chronic thyrotoxic myopathy development is associated with thyroid hormone sensitivity index, predicted by lower-limb fatigue and the squat-up test.

Autor: Fu SE; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China.; Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China., Liang XH; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Huang LL; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China.; Department of Endocrinology, The Affiliated Hospital of Guilin Medical University, No.15 Le Qun Road, Guilin, 541001, China., Xian J; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Wu XZ; Department of Laboratory, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Pan J; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Chen XL; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Kuang YQ; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Wu CJ; Department of Laboratory, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Li QL; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Liu XF; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Huang ZE; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Wei TT; Department of Laboratory, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Qin YF; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Huang ZX; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Yang HY; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Lan SS; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China., Lu DC; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China. 237540679@qq.com., Luo ZJ; Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Road, Nanning, 530021, China. luozuojie@gxmu.edu.cn.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 17; Vol. 14 (1), pp. 24364. Date of Electronic Publication: 2024 Oct 17.
DOI: 10.1038/s41598-024-76273-5
Abstrakt: Thyroid hormones (THs) may affect chronic thyrotoxic myopathy (CTM). The relationship between TH sensitivity and CTM is inconsistent. We aimed to investigate the associations between TH sensitivity and the risk of CTM and to screen potential CTMs with strength and function tests. A total of 162 Chinese patients (36.58% men) with Graves' disease were enrolled and divided into CTM and non-CTM groups. TH and sensitivity indices were measured. Muscle power and function were assessed by grip, upper-limb fatigue (ULFT), lower-limb fatigue (LLFT), and squat-up (SUT) tests, and walking pace. Association between sensitivity to TH indices and the risk of developing CTM was assessed via multivariate logistic regression. The diagnostic effectiveness of muscle power and function for predicting CTM was evaluated via receiver operating characteristic (ROC) curves. Thyroid feedback quantile-based index FT 3 (TFQI FT3 ) and the parametric TFQI FT3 (PTFQI FT3 ), TFQI FT4 , and PTFQI FT4 were positively associated with CTM risk by using inverse probability of treatment weighting multivariate logistic regression. For each 1-SD increase in TFQI FT3 and PTFQI FT3 , TFQI FT4 and PTFQI FT4 , the odds ratios for CTM were 1.67 (95% CI = 1.17-2.48) ,1.64 (95% CI = 1.51-2.93), 1.60 (95%CI = 1.12-2.32), 1.58 (95%CI = 1.11-2.30), respectively. LLFT and SUT best predicted male/female CTM, respectively (AUC = 0.89/0.85). In Graves' disease patients, TH sensitivity is associated with CTM development, which can be predicted by SUT and LLFT results.
(© 2024. The Author(s).)
Databáze: MEDLINE
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