The human claustrum tracks slow waves during sleep.

Autor: Lamsam L; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, USA., Gu B; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, USA., Liang M; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, USA., Sun G; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, USA., Khan KJ; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, USA., Sheth KN; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, USA.; Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA., Hirsch LJ; Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.; Department of Neurology, Yale School of Medicine, Comprehensive Epilepsy Center, Yale University, New Haven, CT, USA., Pittenger C; Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA.; Department of Psychology, Yale University, New Haven, CT, USA.; Child Study Center, Yale School of Medicine, Yale University, New Haven, CT, USA.; Center for Brain and Mind Health, Yale University, New Haven, CT, USA., Kaye AP; Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA.; Clinical Neurosciences Division, VA National Center for PTSD, West Haven, CT, USA., Krystal JH; Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA.; Department of Psychology, Yale University, New Haven, CT, USA.; Clinical Neurosciences Division, VA National Center for PTSD, West Haven, CT, USA.; Department of Neuroscience, Yale School of Medicine, Yale University, New Haven, CT, USA., Damisah EC; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, USA. eyiyemisi.damisah@yale.edu.; Wu Tsai Institute, Yale University, New Haven, CT, USA. eyiyemisi.damisah@yale.edu.; Center for Brain and Mind Health, Yale University, New Haven, CT, USA. eyiyemisi.damisah@yale.edu.; Department of Neuroscience, Yale School of Medicine, Yale University, New Haven, CT, USA. eyiyemisi.damisah@yale.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Oct 17; Vol. 15 (1), pp. 8964. Date of Electronic Publication: 2024 Oct 17.
DOI: 10.1038/s41467-024-53477-x
Abstrakt: Slow waves are a distinguishing feature of non-rapid-eye-movement (NREM) sleep, an evolutionarily conserved process critical for brain function. Non-human studies suggest that the claustrum, a small subcortical nucleus, coordinates slow waves. We show that, in contrast to neurons from other brain regions, claustrum neurons in the human brain increase their spiking activity and track slow waves during NREM sleep, suggesting that the claustrum plays a role in coordinating human sleep architecture.
(© 2024. The Author(s).)
Databáze: MEDLINE
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