Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats.

Autor: Klim H; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK. hannah.klim@ndm.ox.ac.uk., William T; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; Gleneagles Hospital, Kota Kinabalu, Malaysia.; Clinical Research Centre, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia., Mellors J; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Brady C; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Rajahram GS; Clinical Research Centre, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia., Chua TH; Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia.; EduLife Berhad, Penampang, Sabah, Malaysia., Brazal Monzó H; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., John JL; Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia., da Costa K; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Medway, Kent, UK., Jeffree MS; Department of Public Health Medicine, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia., Temperton NJ; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Medway, Kent, UK., Tipton T; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Thompson CP; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK., Ahmed K; Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia.; Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia.; Research Center for Global and Local Infectious Disease, Oita University, Oita, Japan., Drakeley CJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Carroll MW; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Fornace KM; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. kfornace@nus.edu.sg.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. kfornace@nus.edu.sg.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Oct 17; Vol. 15 (1), pp. 8863. Date of Electronic Publication: 2024 Oct 17.
DOI: 10.1038/s41467-024-53058-y
Abstrakt: Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malaysian Borneo, but HPAI has circulated in poultry and migratory avian species transiting through the region. Recent deforestation in coastal habitats in Malaysian Borneo may increase the proximity between humans and migratory birds. We hypothesise that higher rates of human-animal contact, caused by this habitat destruction, will increase the likelihood of potential zoonotic spillover events. In 2015, an environmentally stratified cross-sectional survey was conducted collecting geolocated questionnaire data in 10,100 individuals. A serological survey of these individuals reveals evidence of H5 neutralisation that persisted following depletion of seasonal H1/H3 HA binding antibodies from the plasma. The presence of these antibodies suggests that some individuals living near migratory sites may have been exposed to H5 HA. There is a spatial and environmental overlap between individuals displaying high H5 HA binding and the distribution of migratory birds. We have developed a novel surveillance approach including both spatial and serological data to detect potential spillover events, highlighting the urgent need to study cross-species pathogen transmission in migratory zones.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: