H + -translocating pyrophosphatases in protozoan parasites.

Autor: Araujo-Ruiz K; Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508 Col. Zacatenco, Ciudad de México, 07360, México., Mondragón-Flores R; Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508 Col. Zacatenco, Ciudad de México, 07360, México. rmflores@cinvestav.mx.
Jazyk: angličtina
Zdroj: Parasitology research [Parasitol Res] 2024 Oct 18; Vol. 123 (10), pp. 353. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1007/s00436-024-08362-3
Abstrakt: Integral membrane pyrophosphatases (mPPases) hydrolyze pyrophosphate. This enzymatic mechanism is coupled with the pumping of H + and/or Na + across membranes, which can be either K + -dependent or K + -independent. Inorganic proton-translocating pyrophosphatases (H + -PPases) can transport protons across cell membranes and are reported in various organisms such as plants, bacteria, and protozoan parasites. The evolutionary implications of these enzymes are of great interest for proposing approaches related to the treatment of parasitic of phytopathogenic diseases. This work presents a literature review on pyrophosphate, pyrophosphatases, their inhibitors and emphasizes H + -PPases found in various medically significant protozoan parasites such as Toxoplasma gondii, the causative agent of toxoplasmosis, and Plasmodium falciparum, the causative agent of malaria, as well as protozoan species that primarily affect animals, such as Eimeria maxima and Besnoitia besnoiti.
(© 2024. The Author(s).)
Databáze: MEDLINE
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