Adenosine 2A Receptors Link Astrocytic Alpha-1 Adrenergic Signaling to Wake-Promoting Dopamine Neurons.
Autor: | Petersen N; Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA., McCann KE; Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Stavarache MA; Neurosurgery, Weill Cornell Medical College, New York, NY, 10065, USA., Kim LY; School for Science and Math at Vanderbilt, Nashville, TN, 37232, USA., Weinshenker D; Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Winder DG; Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA; Department of Neurobiology, UMass Chan Medical School, Worcester, MA, 01605, USA. Electronic address: danny.winder@umassmed.edu. |
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Jazyk: | angličtina |
Zdroj: | Biological psychiatry [Biol Psychiatry] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15. |
DOI: | 10.1016/j.biopsych.2024.09.030 |
Abstrakt: | Background: Sleep and arousal disorders are common, but the underlying physiology of wakefulness is not fully understood. The locus coeruleus promotes arousal via alpha-1 adrenergic receptor (α Methods: In this study, we utilized genetic manipulations with ex vivo calcium imaging in vPAG DA neurons and astrocytes, patch-clamp electrophysiology, and behavioral experiments in mice to probe our hypothesis that astrocytic α Results: Activation of α Conclusions: We have identified a crucial role for vPAG astrocytic α (Copyright © 2024. Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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