Impact of childhood exposure to traffic related air pollution on adult cardiometabolic health: Exploring the role of perceived stress.

Autor: Guo F; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Habre R; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA; Spatial Sciences Institute, University of Southern California, Los Angeles, CA, USA., Xu Y; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Chen X; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Howland S; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Lurmann F; Sonoma Technology Inc., Petaluma, CA, USA., Pavlovic N; Sonoma Technology Inc., Petaluma, CA, USA., Gauderman WJ; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., McConnell R; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Bastain TM; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Breton CV; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Farzan SF; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA. Electronic address: sffarzan@usc.edu.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Oct 16; Vol. 263 (Pt 2), pp. 120130. Date of Electronic Publication: 2024 Oct 16.
DOI: 10.1016/j.envres.2024.120130
Abstrakt: Background: Little is known about how childhood exposure to traffic-related air pollution (TRAP) and stress interact to affect adults' cardiometabolic health. We examined this interaction and assessed the impact of over 10 years of childhood TRAP exposure on cardiometabolic health.
Methods: From 2018 to 2023, 313 young adults from the Southern California Children's Health Study were enrolled in a follow-up assessment. Using CALINE4 line source dispersion model, average childhood TRAP exposures (from pregnancy to age 13) were estimated for nitrogen oxides (NO x ) from all roads. Traffic density was calculated within a 300-m residential buffer. Cardiometabolic health was assessed in adulthood (mean age 24 ± 1.7) based on blood lipids (total cholesterol, high- and low-density lipoprotein [HDL, LDL], triglycerides), glucose metabolism (fasting glucose, fasting insulin, HbA1c), body composition (BMI, android/gynoid ratio [AG ratio], percent body fat), and blood pressure. A PDAY (Pathobiologic Determinants of Atherosclerosis in Youth) score was generated to evaluate overall cardiometabolic health. Participants' perceived stress was assessed in childhood and adulthood (ages 13 and 24 years, respectively).
Results: Results of mixed effects linear models, adjusted for demographics and smoking status, suggested that each standard deviation increase in childhood exposure to traffic-related total NO x was associated with 0.62 increase in PDAY score (95% Confidence Interval [CI]:0.10,1.14), 0.09% increase in HbA1c (95%CI: 0.04, 0.15), 1.19% increase in percent body fat (95%CI: 0.18, 2.20), and 0.96 kg/m 2 increase in BMI (0.11, 1.80) in adulthood. Among participants with higher childhood stress levels, we observed significant associations of traffic-related total NO x with total cholesterol, HDL, LDL, HbA1c, insulin, and BMI. None of these associations were significant among people with lower stress levels. We observed similar statistically significant associations of traffic density.
Conclusion: Long-term childhood exposure to TRAP in childhood may have lasting adverse impacts on cardiometabolic health, especially for children with higher stress levels.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Shohreh Farzan reports financial support was provided by National Institutes of Health. Breton, Bastain, Habre reports financial support was provided by National Institutes of Health. Shohreh Farzan reports a relationship with University of Southern California that includes: employment. Guo, Habre, Xu, Chen, Howland, Gauderman, Bastain, Breton reports a relationship with University of Southern California that includes: employment. Lurmann, Pavlovic reports a relationship with Sonoma Technology Inc that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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