Temporal trajectories of long-COVID symptoms in adults with 22 months follow-up in a prospective cohort study in Norway.

Autor:	Ellingjord-Dale M; Department of Microbiology, Oslo University Hospital, Nydalen, Oslo, Norway. Electronic address: mellingjord@hotmail.com., Nygaard AB; Department of Microbiology, Oslo University Hospital, Nydalen, Oslo, Norway., Støer NC; Research Department, Cancer Registry of Norway, Oslo, Norway., Bø R; Department of Psychology, University of Oslo, Oslo, Norway., Landrø NI; Department of Psychology, University of Oslo, Oslo, Norway., Brunvoll SH; Department of Microbiology, Oslo University Hospital, Nydalen, Oslo, Norway., Istre M; Department of Microbiology, Oslo University Hospital, Nydalen, Oslo, Norway., Kalleberg KT; Age Labs AS, Oslo, Norway., Dahl JA; Department of Microbiology, Oslo University Hospital, Nydalen, Oslo, Norway., Geng L; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Tsilidis K; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, UK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., Riboli E; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, UK., Ursin G; Cancer Registry of Norway, University of Oslo, Oslo, Norway; Department of Nutrition, Institute of Basic Medical Sciences, Oslo, Norway; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA., Søraas A; Department of Microbiology, Oslo University Hospital, Nydalen, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Oct 15; Vol. 149, pp. 107263. Date of Electronic Publication: 2024 Oct 15.
DOI:	10.1016/j.ijid.2024.107263
Abstrakt:	Objectives: There is a lack of large studies on long-COVID symptoms with symptoms measurements before the onset of COVID-19. Therefore, long-COVID is still poorly defined. Methods: The Norwegian COVID-19 Cohort Study is a population-based, open cohort of adult participants (aged 18-96 years) from Norway. From March 27, 2020, participants were recruited through social media, invitations, and nationwide media coverage. Fourteen somatic and cognitive symptoms were assessed at baseline and four follow-ups for up to 22 months. SARS-CoV-2 test status was obtained from a mandatory national registry or from self-report. Results: After follow-up, 15 737 participants had a SARS-CoV-2-positive test, 67 305 had a negative test, and 37 563 were still untested. Persistent symptoms reported more frequently by positive compared with negative participants one month after infection, were memory problems (3-6 months: adjusted odds ratio (aOR) = 6.8, CI = 5.7-8.1; >18 months: aOR = 9.4, CI = 4.1-22), and concentration problems (3-6 months: aOR = 4.1, CI = 3.5-4.7; >18 months: aOR = 4.4, CI = 2.0-9.7) as well fatigue, dyspnea, anosmia and dysgeusia. Conclusions: COVID-19 was associated with cognitive symptoms, anosmia, dysgeusia, dyspnea, and fatigue as well as worsening of overall health up to 22 months after a SARS-CoV-2 test, even when correcting for symptoms before the onset of COVID-19. Competing Interests: Declaration of competing interest All authors declared no potential conflicts of interest. However, Karl Trygve Kalleberg and Arne Søraas are founders and shareholders of the company Age Labs AS which develops epigenetic tests, including one for COVID-19 severity. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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