Six new phenolic glycosides from the roots of Scrophularia ningpoensis.

Autor: Li YC; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China., Liu P; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; Nanyang Institute of Technology, Nanyang 473000, China., Su YY; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China., Xu C; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China., Sun M; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China., Zhang W; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; The Key Research Laboratory of 'Exploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine', The State Administration of Traditional Chinese Medicine, Beijing 102488, China; National Administration of Traditional Chinese Medicine High level Key Discipline Construction Project of Traditional Chinese Medicine-Chemistry of Chinese Materia Medica, China. Electronic address: zhangwei_bucm@163.com., Liu B; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; The Key Research Laboratory of 'Exploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine', The State Administration of Traditional Chinese Medicine, Beijing 102488, China; National Administration of Traditional Chinese Medicine High level Key Discipline Construction Project of Traditional Chinese Medicine-Chemistry of Chinese Materia Medica, China. Electronic address: liubinyn67@163.com.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Dec; Vol. 179, pp. 106258. Date of Electronic Publication: 2024 Oct 16.
DOI: 10.1016/j.fitote.2024.106258
Abstrakt: Six new phenolic glycosides (1-6) and thirteen known compounds (7-19) were isolated from the roots of Scrophularia ningpoensis. Their structures were determined through comprehensive analyses of the physicochemical properties and spectroscopic data (1D NMR, 2D NMR, and HR-ESI-MS). The anti-inflammatory potential of all compounds was evaluated by determining their ability to inhibit lipopolysaccharide (LPS) induced NO production in RAW 264.7 macrophage cells. In addition, the cytotoxicity of all compounds on HepG2, 4T1 and A549 cell lines was also evaluated.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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