Synthesis, Characterization, and Biological Activity of New 4'-Functionalized Bis-Terpyridine Ruthenium(II) Complexes: Anti-Inflammatory Activity Advances.

Autor: Elnagar MM; Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, 89081, Ulm, Germany.; Department of Inorganic Chemistry, National Research Centre, 33 El Bohouth St. (former Tahrir St.), 12622, Dokki, Giza, Egypt., Abou-El-Sherbini KS; Department of Inorganic Chemistry, National Research Centre, 33 El Bohouth St. (former Tahrir St.), 12622, Dokki, Giza, Egypt., Samir S; Department of Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, P.O. Box 30, Giza, Egypt., Sharmoukh W; Department of Inorganic Chemistry, National Research Centre, 33 El Bohouth St. (former Tahrir St.), 12622, Dokki, Giza, Egypt., Abdel-Aziz MS; Department of Microbial Chemistry, National Research Centre, 33 El Bohouth St. (former Tahrir St.), 12622, Dokki, Giza, Egypt., Shaker YM; Division of Pharmaceutical and Drug Industries, Department of the Chemistry of Natural and Microbial Products, National Research Centre, El Buhouth Street, Dokki, Cairo, 12622, Egypt.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Oct 17, pp. e202400680. Date of Electronic Publication: 2024 Oct 17.
DOI: 10.1002/cmdc.202400680
Abstrakt: Ruthenium complexes incorporating 2,2' : 6',2''-terpyridine ligands have emerged as promising candidates due to their versatile biological activities including DNA-binding, anti-inflammatory, antimicrobial, and anticancer properties. In this study, three new 4'-functionalized bis(terpyridine) Ru(II) complexes were synthesized. These complexes feature one ligand as 4-(2,2' : 6',2''-terpyridine-4'-yl) benzoic acid and the second ligand as either 4'-(2-thienyl)-2,2' : 6',2''-terpyridine, 4'-(3,4-dimethoxyphenyl)-2,2' : 6',2''-terpyridine, or 4'-(4-dimethylaminophenyl)-2,2' : 6',2''-terpyridine. Besides the chemical characterization by 1 H and 13 C NMR, mass spectrometry, and absorption and emission spectroscopy, the complexes were tested for their biological activity as anti-inflammatory, anticancer, and antimicrobial agents. Moreover, the toxicity of the Ru(II) complexes was assessed and benchmarked against diclofenac potassium and ibuprofen using a haemolysis assay. Biological evaluations demonstrate that these ruthenium complexes exhibit promising therapeutic potential with reduced haemolytic activity compared to standard drugs. They demonstrate substantial anti-inflammatory effects through inhibition of albumin denaturation along with moderate cytotoxicity against cancer cell lines and broad-spectrum antimicrobial activity. These findings highlight the multifaceted biomedical applications of 4'-functionalized bis(terpyridine) Ru(II) complexes, suggesting their potential for further development as effective and safe therapeutic agents.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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