Smart Biopolymer Scaffolds Based on Hyaluronic Acid and Carbonyl Iron Microparticles: 3D Printing, Magneto-Responsive, and Cytotoxicity Study.

Autor:	Gorgol D; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic., Mrlík M; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic., Mikulka F; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavřečkova 275, 70 01 Zlin, Czech Republic., Víchová Z; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic., Mahelová L; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic., Ilčíková M; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic.; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavřečkova 275, 70 01 Zlin, Czech Republic.; Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, 845 45 Bratislava, Slovakia., Minařík A; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic.; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavřečkova 275, 70 01 Zlin, Czech Republic.
Jazyk:	angličtina
Zdroj:	ACS applied bio materials [ACS Appl Bio Mater] 2024 Nov 18; Vol. 7 (11), pp. 7483-7493. Date of Electronic Publication: 2024 Oct 17.
DOI:	10.1021/acsabm.4c00567
Abstrakt:	This study deals with utilization of the hyaluronic acid (HA) and carbonyl iron (CI) microparticles to fabricate the magneto-responsive hydrogel scaffolds that can provide triggered functionality upon application of an external magnetic field. The various combinations of the HA and CI were investigated from the rheological and viscoelastic point of view to clearly show promising behavior in connection to 3D printing. Furthermore, the swelling capabilities with water diffusion kinetics were also elucidated. Magneto-responsive performance of bulk hydrogels and their noncytotoxic nature were investigated,, and all hydrogels showed cell viability in the range 75-85%. The 3D printing of such developed systems was successful, and fundamental characterization of the scaffolds morphology (SEM and CT) has been presented. The magnetic activity of the final scaffolds was confirmed at a very low magnetic field strength of 140 kA/m, and such a scaffold also provides very good biocompatibility with NIH/3T3 fibroblasts.
Databáze:	MEDLINE
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