| Autor: |
Hu Y; Wageningen University & Research, Wageningen Livestock Research, 6700 AH Wageningen, the Netherlands.; Wageningen University & Research, Animal Nutrition Group, 6700 AH Wageningen, the Netherlands.; Current address Global R&D Department, De Heus Animal Nutrition B.V, 6717 VE Ede, the Netherlands., Bikker P; Wageningen University & Research, Wageningen Livestock Research, 6700 AH Wageningen, the Netherlands., Hendriks WH; Wageningen University & Research, Animal Nutrition Group, 6700 AH Wageningen, the Netherlands., van Krimpen MM; Wageningen University & Research, Wageningen Livestock Research, 6700 AH Wageningen, the Netherlands., van Baal J; Wageningen University & Research, Animal Nutrition Group, 6700 AH Wageningen, the Netherlands. |
| Jazyk: |
angličtina |
| Zdroj: |
The British journal of nutrition [Br J Nutr] 2024 Oct 17, pp. 1-23. Date of Electronic Publication: 2024 Oct 17. |
| DOI: |
10.1017/S0007114524002332 |
| Abstrakt: |
Enhanced dietary Ca intake linearly increases intestinal Ca absorption in pigs, but not in broilers, suggesting potential differences in whole body Ca homeostasis. To determine the role of kidney in Ca homeostasis in these species, we varied in growing pigs in experiment ( Exp ) 1, the dietary Ca content 2.0 vs. 9.6 g/kg and phytase 0 vs. 500 FTU/kg, in broilers, in Exp 2 the dietary Ca/retainable P from 1.3 to 2.8 and phytase 0 vs. 1000 FTU/kg, and in Exp 3 dietary Ca/P from 0.50 to 1.75. Increasing dietary Ca reduced renal mRNA expression of Ca-related transporters (TRPV5, TRPV6, CaBP-D28k, NCX1) and tight junctions (CLDN-12 and -16) in pigs, indicating Ca reabsorption was reduced to maintain Ca homeostasis. In broilers (Exp 2), high dietary Ca increased renal TRPV6, CaBP-D28k and CLDN-2 mRNA, indicating an increased capacity for Ca reabsorption. Moreover, the effect of dietary Ca was enhanced by inclusion of dietary phytase in pigs but reduced in broilers. Furthermore, increasing dietary Ca upregulated PiT-1 while phytase downregulated XPR1 mRNA expression in pigs; in broilers dietary Ca downregulated renal mRNA expression of NaPi-IIa, PiT-1, PiT-2 and XPR1, while phytase downregulated NaPi-IIa but upregulated PiT-2 and XPR1 mRNA expression. In Exp 3, Ca/P effect on transporter mRNA expression was largely consistent with Exp 2. In conclusion of this study, together with previously measured data about Ca and P homeostasis, in pigs the kidneys play a more regulatory role in Ca homeostasis than in broilers where the intestine is more important for regulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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