Multidisciplinary and personalized approach to the management of mycosis fungoides with chlormethine gel: a collection of clinical experiences.

Autor:	Violetti SA; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Ardigò M; Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy., Fava P; Department of Medical Sciences, Dermatology Section, University of Turin, Turin, Italy., Gritti G; Hematology and BMT Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Morsia E; Hematology Department, University of Ancona, Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona, Ancona, Italy., Onida F; Hematology and BMT Unit, ASST Fatebenefratelli-Sacco - University of Milan, Italy., Paulli M; Unità di Anatomia Patologica, Dipartimento di Medicina Molecolare, Università degli Studi di Pavia, Pavia, Italy., Pileri A; Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Quaglino P; Department of Medical Sciences, Dermatology Section, University of Turin, Turin, Italy., Rupoli S; Hematology Department, University of Ancona, Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona, Ancona, Italy., Teoli M; Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute - IRCCS, via Chianesi 53, 00144 Rome, Italy., Vezzoli P; Dermatology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
Jazyk:	angličtina
Zdroj:	Drugs in context [Drugs Context] 2024 Oct 10; Vol. 13. Date of Electronic Publication: 2024 Oct 10 (Print Publication: 2024).
DOI:	10.7573/dic.2024-6-1
Abstrakt:	Topical chlormethine (CL) gel formulation was approved by the EMA in 2017 for the treatment of adult patients with mycosis fungoides (MF). To expand the knowledge on the management of MF, this paper provides an overview of clinical practice evidence about the MF diagnostic phase and a collection of clinical experiences to better characterize the use of CL gel in daily practice. Collected cases underline the importance of the concomitant biopsy and clinical evaluation in the diagnostic phase, with the contribution of a multidisciplinary team, and support the use of CL gel as a first-line or adjuvant treatment in selected patients. Competing Interests: Disclosure and potential conflicts of interest: SAV has received speaking honoraria and advisory board fees from Takeda, Kyowa Kirin and Recordati and advisory board fees from Recordati. FO has received speaking honoraria from Takeda, Medac, Kyowa Kirin, Menarini-Stemline and Recordati, advisory board fees from Rercordati, and travel support from Medac, Jazz and Janssen. GG reports consultancy fees from Genmab, Roche, Abbvie, Ideogen, Kite-Gilead and Takeda, and travel support from Gilead Kite, Janssen and Beigene. PQ received advisory board and speaker fees from Kyowa Kirin, Takeda, Helsinn, Recordati, Cellgene, Innate Pharma and Therakos. MA has received speaking honoraria and advisory board fees from Takeda, Pierre Fabre, Kyowa Kirin, Helsinn, Recordati, Almirall and Cantabria. AP has received consulting and advisory board fees from Kyowa Kyrin, Menarini Stemline and Recordati. SR has received speaking honoraria from Takeda, Kyowa Kirin and Recordati. MT has received support and advisory board fees from Kyowa Kirin, Boehringer Ingelheim and Recordati. MP has received invited speaker/advisory board feed from Menarini, Kyowa Kirin and Recordati. All other authors declare no conflict of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2024/09/dic.2024-6-1-COI.pdf (Copyright © 2024 Alberti Violetti S, Ardigò M, Fava P, Gritti G, Morsia E, Onida F, Paulli M, Pileri A, Quaglino P, Rupoli S, Teoli M, Vezzoli P.)
Databáze:	MEDLINE
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