Myeloma-associated hemophagocytic lymphohistiocytosis - A comprehensive case study and a novel chemotherapy-free approach with anakinra.

Autor: Al-Ammari M; Department of Haematology Liverpool Hospital Liverpool Australia., Hsu D; Department of Haematology Liverpool Hospital Liverpool Australia.; School of Clinical Medicine University of New South Wales Sydney Australia., Bryant A; Department of Haematology Liverpool Hospital Liverpool Australia.; School of Clinical Medicine University of New South Wales Sydney Australia.
Jazyk: angličtina
Zdroj: EJHaem [EJHaem] 2024 Jul 04; Vol. 5 (5), pp. 1057-1062. Date of Electronic Publication: 2024 Jul 04 (Print Publication: 2024).
DOI: 10.1002/jha2.975
Abstrakt: Hemophagocytic lymphohistiocytosis (HLH) is an immune response syndrome characterized by excessive inflammation and tissue destruction. A limited number of cases involving HLH patients with concomitant multiple myeloma (MM), leading to significant mortality, have been documented, underscoring the importance of timely diagnosis. We present the case of a 78-year-old previously healthy male admitted to our hospital with a newly diagnosed MM. Subsequently, he was diagnosed with HLH and received treatment with anakinra, intravenous immunoglobulin, and dexamethasone. This case report highlights the unique aspect of being the first documented instance of myeloma-associated HLH treated with anakinra.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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