High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition.

Autor: Song Y; Oral Genomics Research Center, Pusan National University, Yangsan, Republic of Korea.; Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, 50162, Republic of Korea., Kwon JJ; Department of Dentistry, Yeungnam University College of Medicine, Daegu, Republic of Korea., Na HS; Oral Genomics Research Center, Pusan National University, Yangsan, Republic of Korea.; Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, 50162, Republic of Korea., Kim SY; Oral Genomics Research Center, Pusan National University, Yangsan, Republic of Korea.; Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, 50162, Republic of Korea., Shin SH; Department of Oral and Maxillofacial Surgery, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, 50162, Republic of Korea. ssh8080@pusan.ac.kr.; Dental and Life Science Institute, Pusan National University, Busan, Republic of Korea. ssh8080@pusan.ac.kr., Chung J; Oral Genomics Research Center, Pusan National University, Yangsan, Republic of Korea. jchung@pusan.ac.kr.; Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, 50162, Republic of Korea. jchung@pusan.ac.kr.
Jazyk: angličtina
Zdroj: BMC immunology [BMC Immunol] 2024 Oct 17; Vol. 25 (1), pp. 69. Date of Electronic Publication: 2024 Oct 17.
DOI: 10.1186/s12865-024-00655-7
Abstrakt: Background: Porphyromonase gingivalis (P. gingivalis) is a type of bacteria that causes periodontitis, which is strongly correlated with systemic diseases such as diabetes. However, the effect of hyperglycemia on periodontitis are unclear. The present study examined the effects of high glucose levels on the response to P. gingivalis infection.
Results: The expression of P. gingivalis-induced interleukin-1β (IL-1β) and inflammasomes increased as the glucose concentration increased. High glucose conditions suppressed P. gingivalis-induced autophagy in human acute monocytic leukemia cell line (THP-1) macrophages. Zingerone increased autophagy and alleviated P. gingivalis-induced inflammatory response in THP-1 macrophages under high glucose conditions. In addition, P. gingivalis- induced inflammation in bone marrow-derived macrophages of diabetic mice was higher than in wild-type mice, but a zingerone treatment decreased the levels. Alveolar bone loss due to a P. gingivalis infection was significantly higher in diabetic mice than in wild-type mice.
Conclusions: High-glucose conditions aggravated the inflammatory response to P. gingivalis infection by suppressing of autophagy, suggesting that autophagy induction could potentially to treat periodontitis in diabetes. Zingerone has potential use as a treatment for periodontal inflammation induced by P. gingivalis in diabetes patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
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