Semi-synthesis of a DNA-Tagged Polyketide-Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component.
| Autor: | Koremura S; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Sugawara A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Morishita Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Ozaki T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Asai T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2024 Oct 25; Vol. 26 (42), pp. 9151-9156. Date of Electronic Publication: 2024 Oct 16. |
| DOI: | 10.1021/acs.orglett.4c03588 |
| Abstrakt: | Presented herein is a synthetic biological method using genome mining and heterologous expression systems that provides access to natural products with desirable structural features as building blocks. In this investigation, we synthesized polyketide-peptide hybrid macrocycles with DNA tags, which have the potential to access a DNA-encoded library containing over one million compounds. This study demonstrates that synthetic biology offers a tool for expanding the diversity of building blocks, facilitating the exploration of unexplored chemical space. |
| Databáze: | MEDLINE |
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