Impact of graphical display on the intention to undergo risk-reducing salpingo-oophorectomy and mastectomy in individuals positive for BRCA pathogenic variant.

Autor: Choi YJ; Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.; National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.; Center for Cancer Prevention & Detection, National Cancer Center Hospital, Goyang, Republic of Korea., Park Y; National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea., Park B; Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea., Chae H; Center for Breast Cancer, National Cancer Center Hospital, Goyang, Republic of Korea., Jung SY; Center for Breast Cancer, National Cancer Center Hospital, Goyang, Republic of Korea., Ryu KH; Center for Cancer Prevention & Detection, National Cancer Center Hospital, Goyang, Republic of Korea., Lim MC; Center for Gynecologic Cancer, National Cancer Center Hospital, Goyang, Republic of Korea., Park SJ; Department of Surgery, Wonkwang University Sanbon Hospital, Gunpo, Republic of Korea., Chang YJ; National Cancer Survivorship Center, National Cancer Control Institute, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea. eunicemd@ncc.re.kr.; Department of Cancer AI & Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea. eunicemd@ncc.re.kr., Kong SY; Targeted Therapy Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea. ksy@ncc.re.kr.; Department of Laboratory Medicine, Hospital, National Cancer Center, Goyang, Republic of Korea. ksy@ncc.re.kr.; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea. ksy@ncc.re.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 16; Vol. 14 (1), pp. 24281. Date of Electronic Publication: 2024 Oct 16.
DOI: 10.1038/s41598-024-73929-0
Abstrakt: The BRCA1/2 pathogenic variant (PV) increases the risk of breast and ovarian cancer; thus, risk-reducing salpingo-oophorectomy (RRSO) and mastectomy (RRM) are recommended. We evaluated the effects of the graphical display of cancer risk compared with those of numerical presentation on the decision-making for risk-reducing (RR) surgery. A total of 471 women representing the Korean population were recruited. The lifetime risk of breast/ovarian cancer were given numerically followed by graphically in hypothetical BRCA1/2 PV-positive cases. Subsequently, the study participants were asked for their willingness to undergo RRSO/RRM. When the ovarian cancer risk was shown as 44.0%, the percentage of study participants who chose RRSO was 41.0% after numerical presentation versus 39.9% after graphical display, of which the difference was not significant. When the breast cancer risk was presented as 72.0%, 30.4% of the participants opted for RRM under numerical presentation, whereas this increased to 38.6% under graphical display, of which the difference was significant (p < 0.0075). The average levels of the cancer risk which study participants consider RR surgery were 57.1% for ovarian cancer and 60.6% for breast cancer. This suggests that the impacts of different formats of risk communication on decision about RRSO or RRM may be different by the absolute levels of ovarian or breast cancer.
(© 2024. The Author(s).)
Databáze: MEDLINE
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