The 75-Year Anniversary of the Department of Physiology and Pharmacology at Karolinska Institutet-Examples of Recent Accomplishments and Future Perspectives.

Autor:	Weitzberg E; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.W., M.I.-S., J.O.L., G.E., G.S., V.M.L.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tübingen, Tübingen, Germany (V.M.L.)., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.W., M.I.-S., J.O.L., G.E., G.S., V.M.L.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tübingen, Tübingen, Germany (V.M.L.)., Lundberg JO; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.W., M.I.-S., J.O.L., G.E., G.S., V.M.L.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tübingen, Tübingen, Germany (V.M.L.)., Engberg G; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.W., M.I.-S., J.O.L., G.E., G.S., V.M.L.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tübingen, Tübingen, Germany (V.M.L.)., Schulte G; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.W., M.I.-S., J.O.L., G.E., G.S., V.M.L.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tübingen, Tübingen, Germany (V.M.L.)., Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.W., M.I.-S., J.O.L., G.E., G.S., V.M.L.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tübingen, Tübingen, Germany (V.M.L.) volker.lauschke@ki.se.
Jazyk:	angličtina
Zdroj:	Pharmacological reviews [Pharmacol Rev] 2024 Oct 16; Vol. 76 (6), pp. 1089-1101. Date of Electronic Publication: 2024 Oct 16.
DOI:	10.1124/pharmrev.124.001433
Abstrakt:	Karolinska Institutet is a medical university encompassing 21 departments distributed across three departmental or campus groups. Pharmacological research has a long and successful tradition at the institute with a multitude of seminal findings in the areas of neuronal control of vasodilatation, cardiovascular pharmacology, neuropsychopharmacology, receptor pharmacology, and pharmacogenomics that resulted in, among many other recognitions, two Nobel prizes in Physiology and Medicine, one in 1970 to Ulf von Euler for his discovery of the processes involved in storage, release, and inactivation of neurotransmitters and the other in 1982 to Sune Bergström and Bengt Samuelsson for their work on prostaglandins and the discovery of leukotrienes. Pharmacology at Karolinska Institutet has over the last decade been ranked globally among the top 10 according to the QS World University Ranking. With the Department of Physiology and Pharmacology now celebrating its 75-year anniversary, we wanted to take this as an opportunity to showcase recent research achievements and how they paved the way for current activities at the department. We emphasize examples from preclinical and clinical research where the dpartment's integrative environment and robust infrastructure have successfully facilitated the translation of findings into clinical applications and patient benefits. The close collaboration between preclinical scientists and clinical researchers across various disciplines, along with a strong network of partnerships within the department and beyond, positions us to continue leading world-class pharmacological research at the Department of Physiology and Pharmacology for decades to come. SIGNIFICANCE STATEMENT: Pharmacological research at Karolinska Institutet has a long and successful history. Given the 75-year anniversary of the Department of Physiology and Pharmacology, this perspective provides an overview of recent departmental achievements and future trajectories. For these developments, interdisciplinary and intersectoral collaborations and a clear focus on result translation are key elements to continue its legacy of world-leading pharmacological research. (Copyright © 2024 by The American Society for Pharmacology and Experimental Therapeutics.)
Databáze:	MEDLINE
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