Comparing the effects of time-restricted eating on glycaemic control in people with type 2 diabetes with standard dietetic practice: A randomised controlled trial.

Autor: Parr EB; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia. Electronic address: evelyn.parr@acu.edu.au., Radford BE; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia., Hall RC; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia., Steventon-Lorenzen N; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia; School of Behavioural and Health Sciences, ACU, Melbourne, VIC, Australia; SPRINT Research and Faculty of Health Sciences, ACU, Melbourne, VIC, Australia., Flint SA; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia., Siviour Z; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia., Plessas C; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia., Halson SL; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, QLD, Australia; SPRINT Research and Faculty of Health Sciences, Brisbane, QLD, Australia., Brennan L; School of Psychology and Public Health, La Trobe University, VIC, Australia., Kouw IWK; Division of Human Nutrition and Health, Wageningen University & Research, the Netherlands., Johnston RD; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, QLD, Australia; SPRINT Research and Faculty of Health Sciences, Brisbane, QLD, Australia; Carnegie Applied Rugby Research (CARR) Centre, Carnegie School of Sport, Leeds Beckett University, United Kingdom., Devlin BL; School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia., Hawley JA; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University (ACU), Melbourne, VIC, Australia; Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, UK.
Jazyk: angličtina
Zdroj: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2024 Nov; Vol. 217, pp. 111893. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1016/j.diabres.2024.111893
Abstrakt: Aims: To test the efficacy of time-restricted eating (TRE) in comparison to dietitian-led individualised dietary guidance to improve HbA1c in people with Type 2 diabetes mellitus.
Methods: In a parallel groups design, 51 adults (35-65 y) with Type 2 diabetes mellitus and overweight/obesity (HbA1c ≥6.5% (48 mmol/mol), BMI ≥25-≤40 kg/m 2 ) commenced a six-month intervention. Following baseline, participants were randomised to TRE (1000-1900 h) or DIET (individualised dietetic guidance) with four consultations over four months. Changes in HbA1c (primary), body composition, and self-reported adherence (secondary) were analysed using linear mixed models. A non-inferiority margin of 0.3% (4 mmol/mol) HbA1c was set a priori.
Results: Forty-three participants (56 ± 8 y, BMI: 33 ± 5 kg/m 2 , HbA1c: 7.6 ± 0.8%) completed the intervention. HbA1c was reduced (P=0.002; TRE: -0.4% (-5 mmol/mol), DIET: -0.3% (-4 mmol/mol)) with no group or interaction effects; TRE was non-inferior to DIET (-0.11%, 95%CI: -0.50% to 0.28%). Body mass reduced in both groups (TRE: -1.7 kg; DIET: -1.2 kg) via ∼900 kJ/d spontaneous energy reduction (P<0.001). Self-reported adherence was higher in TRE versus DIET (P<0.001).
Conclusions: When individualised dietary guidance is not available, effective, and/or suitable, TRE may be an alternative dietary strategy to improve glycaemic control in people with Type 2 diabetes mellitus.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Evelyn B. Parr reports financial support was provided by Diabetes Australia. Evelyn B. Parr reports financial support was provided by Australian Catholic University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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