Fetal body composition reference charts and sexual dimorphism using magnetic resonance imaging.

Autor:	Rabinowich A; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: aviadrabi@gmail.com., Avisdris N; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; School of Computer Science and Engineering, the Hebrew University of Jerusalem, Jerusalem, Israel., Yehuda B; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel., Vanetik S; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Pediatrics, Dana Dwek Children's Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel., Khawaja J; Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Graziani T; Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Neeman B; Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Wexler Y; School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Specktor-Fadida B; School of Computer Science and Engineering, the Hebrew University of Jerusalem, Jerusalem, Israel; Faculty of Social Welfare and Health Sciences, Department of Medical Imaging Sciences, University of Haifa, Haifa, Israel., Herzlich J; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Neonatal Intensive Care Unit, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Joskowicz L; School of Computer Science and Engineering, the Hebrew University of Jerusalem, Jerusalem, Israel; Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Krajden Haratz K; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Obstetrics and Gynecology, Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Hiersch L; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Obstetrics and Gynecology, Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Ben Sira L; Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Ben Bashat D; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
Jazyk:	angličtina
Zdroj:	The American journal of clinical nutrition [Am J Clin Nutr] 2024 Dec; Vol. 120 (6), pp. 1364-1372. Date of Electronic Publication: 2024 Oct 15.
DOI:	10.1016/j.ajcnut.2024.10.004
Abstrakt:	Background: The American Academy of Pediatrics advises that the nutrition of preterm infants should target a body composition similar to that of a fetus in utero. Still, reference charts for intrauterine body composition are missing. Moreover, data on sexual differences in intrauterine body composition during pregnancy are limited. Objectives: The objective of this study was to create reference charts for intrauterine body composition from 30 to 36+6 weeks postconception and to evaluate the differences between sexes. Methods: In this single-center retrospective study, data from 197 normal developing fetuses in late gestation was acquired at 3T magnetic resonance imaging (MRI) scans, including True Fast Imaging with Steady State Free Precession and T 1 -weighted 2-point Dixon sequences covering the entire fetus. Deep convolutional neural networks were utilized to automatically segment the fetal body and subcutaneous adipose tissue. The fetus's body mass (BM), fat signal fraction (FSF), fat mass (FM), FM percentage (FM%), fat-free mass (FFM), and FFM percentage (FFM%) were calculated. Using the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) method, reference charts were created, and sexual dimorphism was examined using analysis of covariance (ANCOVA). A P value <0.05 was deemed significant. Results: Throughout late gestation, BM, FSF, FM, FM%, and FFM increased, while the FFM% decreased. Reference charts for gestational age and sex-specific percentiles are provided. Males exhibited significantly higher BM (7.2%; 95% confidence interval [95% CI]: 1.9, 12.4), FFM (8.8%; 95% CI: 5.8, 11.9), and FFM% (1.7%; 95% CI: 1, 2.4) and lower FSF (-3.6%; 95% CI: -5.6, -1.8) and FM% (-1.7%; 95% CI: -2.4, -1), (P < 0.001) compared with females, with no significant difference in FM between sexes (P = 0.876). Conclusions: MRI-derived intrauterine body composition growth charts are valuable for tracking growth in preterm infants. This study demonstrated that sexual differences in body composition are already present in the intrauterine phase. Competing Interests: Conflict of interest The authors declare that there is no conflict of interest. (Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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