Spontaneous clearance of Chlamydia trachomatis and its associated factors among women attending screening for chlamydia in Shenzhen, China.

Autor:	Zou Q; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Xie Y; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China., Zhang L; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Wu Q; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Ye H; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Ding Y; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Chen W; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Tian L; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Yuan J; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Zhang T; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China., Zheng X; Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Tang W; Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Chen X; National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China., Dai W; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China., Luo Z; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. Electronic address: paulluo9909@163.com.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Dec; Vol. 149, pp. 107269. Date of Electronic Publication: 2024 Oct 15.
DOI:	10.1016/j.ijid.2024.107269
Abstrakt:	Objectives: This study aimed to investigate the factors associated with the spontaneous clearance of Chlamydia trachomatis, a phenomenon that, despite a growing body of literature, remains understudied in the context of women in China. Methods: Spontaneous clearance was defined as the transition from a positive to negative Chlamydia status over time without the use of antichlamydial therapy. Data from 5935 women aged 18 years and older who participated in the Clinical-Based Health Check program were analyzed. Eligible participants had no history of Neisseria gonorrhoeae infection, pelvic inflammatory disease, recent antibiotic use, or pregnancy and had an interval between the screening and follow-up visits of more than 3 days. Logistic regression was used to identify factors influencing spontaneous clearance. Results: Spontaneous clearance occurred in 23.9% (50/209) of the participants, typically with a median interval of 27 days. Significant factors included an interval >45 days, an age >35 years, the use of an intrauterine device (IUD), and the presence of clue cells. Conclusion: Spontaneous clearance of C. trachomatis is significantly affected by age, the interval between two tests, IUD use, and the presence of clue cells. Screening strategies should prioritize women under 35 years of age who do not use IUDs and test negative for clue cells for more effective chlamydia prevention and management. Competing Interests: Declarations of competing interest We declare no potential conflict of interests. The manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us. We understand that the Corresponding Author is the sole contact for the Editorial process. He is responsible for communicating with the other authors about progress, submission of revisions, and final approval of proofs. (Copyright © 2024. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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