| Autor: |
Chen Z; Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, P. R. China. caodongsheng2017@163.com., Zhao X; Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, P. R. China. okcxl@126.com., Lin L; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, 230032, P. R. China., Cui Y; Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, P. R. China. caodongsheng2017@163.com., Cao D; Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, P. R. China. caodongsheng2017@163.com., Chen XL; Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, P. R. China. okcxl@126.com., Wang X; Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, P. R. China. caodongsheng2017@163.com.; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, 230032, P. R. China. |
| Abstrakt: |
Acute wounds result from damage to the skin barrier, exposing underlying tissues and increasing susceptibility to bacterial and other pathogen infections. Improper wound care increases the risk of exposure and infection, often leading to chronic nonhealing wounds, which cause significant patient suffering. Early wound repair can effectively prevent the development of chronic nonhealing wounds. In this study, Ca-Gallic Acid (CaGA) nanozymes with multienzyme catalytic activity were constructed for treating acute wounds by coordinating Ca ions with gallic acid. CaGA nanozymes exhibit high superoxide dismutase/catalase (SOD/CAT) catalytic activity and good antioxidant performance in vitro . In vitro experiments demonstrated that CaGA nanozymes can effectively promote cell migration, efficiently scavenge ROS, maintain mitochondrial homeostasis, reduce inflammation, and decrease cell apoptosis. In vivo , CaGA nanozymes promoted granulation tissue formation, accelerated collagen fiber deposition, and reconstructed skin appendages, thereby accelerating acute wound healing. CaGA nanozymes have potential clinical application value in wound healing treatment. |
