Copper biomarkers and their relationship with dyslipidemia in women with obesity.

Autor: da Silva LD; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., da Silva NC; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., Chaves BMS; Federal University of Piauí, Teresina, Brazil., Santos LR; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., de Sousa TGV; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., de Oliveira EHS; Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., da Cunha Soares T; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., de Sousa Melo SR; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., Henriques GS; Department of Nursing, Federal University of Minas Gerais, Belo Horizonte, Brazil., de Oliveira FE; Federal University of Piauí, Teresina, Brazil., Severo JS; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., Martins JA; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., Barros EML; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil., de Moura MSB; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., do Nascimento Marreiro D; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Brazil. dilina.marreiro@gmail.com.
Jazyk: angličtina
Zdroj: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2024 Oct 16. Date of Electronic Publication: 2024 Oct 16.
DOI: 10.1007/s10534-024-00641-x
Abstrakt: Adipose tissue dysfunction influences the development of dyslipidemias associated with obesity, however, the mechanisms are still unclear. In this sense, the literature highlights the role of copper in cholesterol synthesis, contributing to the increase in concentrations of this lipid fraction and consequently to the manifestation of dyslipidemia. The objective of the study was to investigate the relationship between copper parameters and lipid profile markers in women with obesity. This is a cross-sectional study involving women aged 20 to 50 years divided into a case group (BMI ≥ 35 kg/m 2 ) and a control group (BMI between 18.5 and 24.9 kg/m 2 ). Copper concentrations in plasma and erythrocytes were determined by inductively coupled plasma optical emission spectrophotometry and ceruloplasmin activity by spectrophotometry. The lipid fractions were analyzed according to the enzymatic colorimetric method, using an automatic biochemical analyzer. Participants with obesity had elevated concentrations of copper in plasma and reduced concentrations in erythrocytes compared to the control group, but there was no significant difference in ceruloplasmin activity between the groups. The research does not identify a correlation between copper parameters and serum concentrations of lipid fractions, which does not allow inferring the role of copper in the manifestation of dyslipidemia in obesity.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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