Metabotropic Glutamate Receptor 5: A Potential Target for Neuropathic Pain Treatment.

Autor:	Manengu C; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China.; School of International Education, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Zhu CH; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Zhang GD; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Tian MM; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Lan XB; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Tao LJ; Department of Pharmacy, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750004, China., Ma L; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Liu Y; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Yu JQ; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China., Liu N; College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China.
Jazyk:	angličtina
Zdroj:	Current neuropharmacology [Curr Neuropharmacol] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.
DOI:	10.2174/1570159X23666241011163035
Abstrakt:	Neuropathic pain, a multifaceted and incapacitating disorder, impacts a significant number of individuals globally. Despite thorough investigation, the development of efficacious remedies for neuropathic pain continues to be a formidable task. Recent research has revealed the potential of metabotropic glutamate receptor 5 (mGlu5) as a target for managing neuropathic pain. mGlu5 is a receptor present in the central nervous system that has a vital function in regulating synaptic transmission and the excitability of neurons. This article seeks to investigate the importance of mGlu5 in neuropathic pain pathways, analyze the pharmacological approach of targeting mGlu5 for neuropathic pain treatment, and review the negative allosteric mGlu5 modulators used to target mGlu5. By comprehending the role of mGlu5 in neuropathic pain, we can discover innovative treatment approaches to ease the distress endured by persons afflicted with this incapacitating ailment. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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