Association of Serum Uric Acid Level and Thyroid Function in Chronic Kidney Disease: A Hospital-Based Cross-Sectional Study From Northeast India.
| Autor: | Boruah P; Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, IND., Ruram A; Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, IND., Baruah AJ; Department of General Surgery, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, IND., Nongtdu B; Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, IND., Barman B; Department of Internal Medicine, All India Institute of Medical Sciences, Guwahati, Guwahati, IND., Sahoo DP; Department of Internal Medicine, All India Institute of Medical Sciences, Guwahati, Guwahati, IND., Nath C; Department of Biochemistry, All India Institute of Medical Sciences, Guwahati, Guwahati, IND., Das J; Department of Biochemistry, All India Institute of Medical Sciences, Guwahati, Guwahati, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Sep 14; Vol. 16 (9), pp. e69392. Date of Electronic Publication: 2024 Sep 14 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.69392 |
| Abstrakt: | Background: Although the prevalence of thyroid dysfunction and hyperuricemia are independently high in patients with chronic kidney disease (CKD), there are limited data showing the association of serum uric acid and thyroid function in those with CKD. Aim and Objectives: The aim of this study was to observe the alteration of both the serum uric acid level and thyroid function in CKD patients and to find the association between both. Materials and Methods: This observational cross-sectional study was conducted in a tertiary care hospital over a period of one year in Northeast India. A total of 50 CKD patients were enrolled. Their demographic profiles were studied. Serum urea, creatinine, thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), free triiodothyronine (FT3), total tetraiodothyronine (TT4), and free tetraiodothyronine (FT4) levels were measured to establish the correlation of serum uric acid along with each of the parameters separately. A p-value of < 0.05 was considered statistically significant. Results: In the CKD patients studied, serum uric acid exhibited positive correlations with serum creatinine (p = 0.001, r = 0.67), serum urea (p = 0.001, r = 0.69), and serum TSH levels (p = 0.001, r = 0.5). Conversely, serum uric acid showed negative correlations with serum TT4 (p = 0.001, r = -0.74), TT3 (p = 0.001, r = -0.6), FT4 (p = 0.001, r = -0.53), and FT3 (p = 0.001, r = -0.58) levels. Conclusion: There was a significant positive correlation between uric acid and TSH levels in CKD patients. Thus, early estimation of both parameters should be considered in CKD patients. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Ethics Committee, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong issued approval NEIGR/IEC/M14/T13/2022. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Boruah et al.) |
| Databáze: | MEDLINE |
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