Course of pregnancy and 10-year observation of twins diagnosed with GCK-MODY in the neonatal period: a case report.
| Autor: | Katra B; Department of Metabolic Diseases, Jagiellonian University Medical College, Kraków, Poland.; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Kraków, Poland., Szopa M; Department of Metabolic Diseases, Jagiellonian University Medical College, Kraków, Poland.; Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Kraków, Poland. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Oct 01; Vol. 15, pp. 1395424. Date of Electronic Publication: 2024 Oct 01 (Print Publication: 2024). |
| DOI: | 10.3389/fendo.2024.1395424 |
| Abstrakt: | Monogenic diabetes accounts for 5% of all incidence of hyperglycemia and Maturity Onset Diabetes of the Young (MODY) is the most common form. In GCK-MODY, one of the most common forms of MODY, hyperglycemia is caused by a mutation of a gene responsible for coding glucokinase. At the clinical level, this condition presents as persistent, moderate and asymptomatic elevated fasting glucose levels and has a relatively low incidence of micro and macro-vascular complications. In general, the treatment of choice is to follow and maintain a healthy lifestyle. The incidence of GCK-MODY during pregnancy is 2% on average (0-6%). In this report, we introduce a case of a woman diagnosed with GCK-MODY during the pregnancy with twins, a boy and a girl, diagnosed with GCK-MODY after birth. We discuss the course of pregnancy, the need for access to fast and uncomplicated genetic diagnostics in utero , and the impact of the MODY diagnosis on the life of the mother and that of her children. In our case, the diagnosis of GCK-MODY was associated with a feeling of relief, after years of uncertainty, and helped to introduce more appropriate eating behaviors and lifestyle changes for both the mother and her children. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Katra and Szopa.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|