Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model.

Autor:	Bravo-Reyna CC; Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico., Miranda-Galván V; Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico., Reyes-Soto G; Oncologic Neurosurgery Unit, Instituto Nacional de Cancerología, Tlalpan, Zip code 14080, Mexico., Vicuña R; Department of Pathology, Hospital Central Sur de Alta Especialidad PEMEX Picacho, Tlalpan, Zip code 14140, Mexico., Alanis-Mendizabal J; Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico., Escobar-Valderrama M; Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico., Arango D; Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico., Bautista CJ; Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico., Ramírez V; Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico., Torres-Villalobos G; Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico.
Jazyk:	angličtina
Zdroj:	World neurosurgery: X [World Neurosurg X] 2024 Sep 26; Vol. 25, pp. 100414. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2025).
DOI:	10.1016/j.wnsx.2024.100414
Abstrakt:	Background: Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology. Methods: An experimental, prospective, cross-sectional study was performed using 42 Wistar rats where we analyzed the effect of Chetomin compared to methylprednisolone administered 1 and 8 h after the spinal cord injury in a murine model. Results: Chetomin administration 8h post-injury decreased IL-6 and VEGF expression; and, and its administration 1h post-injury decreased NF-kB expression. Conclusions: Chetomin has anti-inflammatory effects in acute spinal cord injury, whether these effects are observable with other proinflammatory markers should be investigated. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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