Competitive Adsorption of Phenolic Acids, Secoiridoids, and Flavonoids in Quercetin Molecularly Imprinted Polymers and Application for Fractionation of Olive Leaf Extracts.

Autor:	Almeida A; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal., Martins C; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal., Dias RCS; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal., Costa MRPFN; LSRE, Faculdade de Engenharia da Universidade do Porto, Rua Roberto Frias s/n, 4200-465 Porto, Portugal.
Jazyk:	angličtina
Zdroj:	Journal of chemical and engineering data [J Chem Eng Data] 2024 Feb 28; Vol. 69 (10), pp. 3629-3644. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024).
DOI:	10.1021/acs.jced.3c00543
Abstrakt:	The competitive adsorption of phenolic acids, secoiridoids, and flavonoids in a molecularly imprinted polymer (MIP) functionalized with 4-vinylpiridine (4VP) moieties is analyzed here considering vanillic acid, oleuropein, and quercetin as reference molecules. Measured adsorption isotherms highlight a much stronger binding capacity of the quercetin-MIP particles toward quercetin as compared with vanillic acid and oleuropein. The acquired data were used to design and scale-up sorption/desorption processes aiming at the fractionation of olive leaf extracts. We show that a simple adsorption process, avoiding many pre-preparation steps, is possible when working at a high extract concentration due to the strong binding capacity of the MIP for flavonoids, even when using aqueous mixtures with a large alcoholic content. Solvent-gradient/temperature-swing desorption led to a sequence of fractions with enrichment of non-flavonoids at low alcoholic content while glycosylated flavonoids were enriched in fractions with 40% < alcohol content < 80%. Enrichment factors of 13 and 12 were measured for luteolin-7- O -glucoside and apigenin-7- O -glucoside, respectively. Flavonoid aglycones were enriched in fractions with alcohol content >80% (enrichment factors >20 for luteolin and quercetin). The findings reported here demonstrate the usefulness of the developed materials and sorption/desorption conditions for agricultural residue valorization and circular bioeconomy. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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