| Autor: |
Chaudhary S; Department of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Uranw S; Department of Internal Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Rai B; Department of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Keshary Bhatta N; Department of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Shah GS; Department of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Poudel P; Department of Pediatrics & Adolescent Medicine, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Khanal B; Department of Microbiology, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Shah Kalawar RP; Department of Orthopedics, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Rai N; Oral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Shrestha J; Oral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Shrestha M; Oral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Parajuli S; Oral Cholera Vaccine-Simplified Study (OCV-S), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Gupta BP; Clinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of Korea., Vemula S; Clinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of Korea., Rok Song K; Clinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of Korea., Lynch J; Clinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of Korea., Saluja T; Clinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute (IVI), Seoul, Republic of Korea. |
| Abstrakt: |
Clinical trials (CT) have been the cornerstones in developing medicines, vaccines, and new interventions. Despite tremendous efforts, a CT cannot succeed without participants' involvement. Various factors can affect people's attitude and participation in a CT. Hence, this study was conducted to assess the knowledge and perception of a clinical trial among the participants of a CT at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. This was a population-based descriptive cross-sectional study conducted during 2021-2022. Participants involved in a phase III clinical trial were enrolled, and an in-depth interview was conducted using a semi-structured questionnaire. Demographic information, knowledge and perception about CT were assessed, and a descriptive analysis was done. Among 622 participants, the majority were males (321; 51.6%), literate (587; 94.37%), of indigenous ethnic groups (Janajatis 61.4%), and without previous experience of CT (504; 81.1%). The majority had adequate knowledge (566/622; 91%) and positive perception (595/622; 95.7%) of CT. Most participants (467; 75.1%) had participated in CT to get protection from the particular disease from the provided vaccine and (603; 96.9%) believed CT to benefit mankind. Further studies comparing pre- and post-participation knowledge and perception might be helpful for planning and better management of CTs in such settings. |
