| Autor: |
Medyńska A; Clinical Department of Paediatric Nephrology, Wroclaw Medical University, 50-367 Wrocław, Poland., Chrzanowska J; Clinical Department of Paediatrics, Endocrinology, Diabetology and Metabolic Diseases, Wroclaw Medical University, 50-367 Wrocław, Poland., Zubkiewicz-Kucharska A; Clinical Department of Paediatrics, Endocrinology, Diabetology and Metabolic Diseases, Wroclaw Medical University, 50-367 Wrocław, Poland., Zwolińska D; Clinical Department of Paediatric Nephrology, Wroclaw Medical University, 50-367 Wrocław, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2024 Oct 07; Vol. 25 (19). Date of Electronic Publication: 2024 Oct 07. |
| DOI: |
10.3390/ijms251910769 |
| Abstrakt: |
The impact of obesity on kidney injury and the development of chronic kidney disease (CKD) is well documented. Unfortunately, the early stages of CKD are asymptomatic, leading to a delayed diagnosis and a worse prognosis. There is a need for more sensitive indicators of kidney damage than those currently used. We aimed to assess the usefulness of serum t-CAF, urinary netrin-1, α-GST, π-GST, calbindin, and calprotectin as biomarkers of early kidney damage in obese children and to investigate the relationship between these indicators and the degree of obesity. A total of 125 simple obese, normoalbuminuric children and 33 non-obese children as controls were selected. Patients were divided into 2 subgroups according to SDS BMI (I: 2 ≤ 4, II: >4). Serum t-CAF was significantly higher in the obese group compared to the controls, as were urinary α-GST, netrin-1, π-GST, and calprotectin. No difference was found between the two obese groups. In normoalbuminuric obese children and adolescents without significant metabolic disorders, serum t-CAF may be a new biomarker for the early detection of renal dysfunction, and urinary netrin-1, α-GST, π-GST, and calprotectin may be better indicators for the detection of early tubular damage, independent of the severity of obesity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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