| Autor: |
Xu J; School of Computer Science, Northwestern Polytechnical University, Xi'an 710072, China., Hao J; School of Computer Science, Northwestern Polytechnical University, Xi'an 710072, China., Liao X; School of Computer Science, Northwestern Polytechnical University, Xi'an 710072, China., Shang X; School of Computer Science, Northwestern Polytechnical University, Xi'an 710072, China., Li X; School of Computer Science, Northwestern Polytechnical University, Xi'an 710072, China.; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518063, China. |
| Abstrakt: |
The pathogenesis of cancer is complex, involving abnormalities in some genes in organisms. Accurately identifying cancer genes is crucial for the early detection of cancer and personalized treatment, among other applications. Recent studies have used graph deep learning methods to identify cancer driver genes based on biological networks. However, incompleteness and the noise of the networks will weaken the performance of models. To address this, we propose a cancer driver gene identification method based on self-supervision for graph convolutional networks, which can efficiently enhance the structure of the network and further improve predictive accuracy. The reliability of SSCI is verified by the area under the receiver operating characteristic curves (AUROC), the area under the precision-recall curves (AUPRC), and the F1 score, with respective values of 0.966, 0.964, and 0.913. The results show that our method can identify cancer driver genes with strong discriminative power and biological interpretability. |
