| Autor: |
Xiong ZY; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Li HM; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Qiu CS; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Tang XL; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Liao DQ; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Du LY; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Lai SM; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Huang HX; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Zhang BY; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Kuang L; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China., Li ZH; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China. |
| Abstrakt: |
Background : The causal association of specific gut microbiota with dementia remains incompletely understood. We aimed to access the causal relationships in which one or more gut microbiota account for dementia. Method : Using data from the MiBioGen and FinnGen consortia, we employed multiple Mendelian randomization (MR) approaches including two-sample MR (TSMR), multivariable MR (MVMR), and Bayesian model averaging MR to comprehensively evaluate the causal associations between 119 genera and dementia, and to prioritize the predominant bacterium. Result : We identified 21 genera that had causal effects on dementia and suggested Barnesiella (OR = 0.827, 95%CI = 0.722-0.948, marginal inclusion probability [MIP] = 0.464; model-averaged causal estimate [MACE] = -0.068) and Allisonella (OR = 0.770, 95%CI = 0.693-0.855, MIP = 0.898, MACE = -0.204) as the predominant genera for AD and all-cause dementia. Conclusions : These findings confirm the causal relationships between specific gut microbiota and dementia, highlighting the necessity of multiple MR approaches in gut microbiota analysis, and provides promising genera as potential novel biomarkers for dementia risk. |
