Styphnolobium japonicum Fruit and Germinated Soybean Embryo Complex Extract for Postmenopausal-Symptom Relief.

Autor:	Ahn JW; Department of Marine Bioscience, College of Life Science, Gangneung-Wonju National University, Gangneung 25457, Gangwon, Republic of Korea., Kim HS; Department of Marine Bioscience, College of Life Science, Gangneung-Wonju National University, Gangneung 25457, Gangwon, Republic of Korea., Damodar K; East Coast Life Sciences Institute, College of Life Science, Gangneung-Wonju National University, Gangneung 25457, Gangwon, Republic of Korea.; Huscion MAJIC R&D Center, 331 Pangyo-ro, Seongnam 13488, Gyeonggi, Republic of Korea., Shin HH; Life Science Research Institute, NOVAREX Co., Ltd., Cheongju 28220, Chungbuk, Republic of Korea., Kim KM; Life Science Research Institute, NOVAREX Co., Ltd., Cheongju 28220, Chungbuk, Republic of Korea., Park JY; Glocal University Project Group, Andong National University, 1375 Gyeongdong-ro, Andong 36729, Gyeongbuk, Republic of Korea., Jang SK; Department of Marine Bioscience, College of Life Science, Gangneung-Wonju National University, Gangneung 25457, Gangwon, Republic of Korea.; Huscion MAJIC R&D Center, 331 Pangyo-ro, Seongnam 13488, Gyeonggi, Republic of Korea., Yoo YM; East Coast Life Sciences Institute, College of Life Science, Gangneung-Wonju National University, Gangneung 25457, Gangwon, Republic of Korea., Jung JC; Life Science Research Institute, NOVAREX Co., Ltd., Cheongju 28220, Chungbuk, Republic of Korea., Joo SS; Department of Marine Bioscience, College of Life Science, Gangneung-Wonju National University, Gangneung 25457, Gangwon, Republic of Korea.; Huscion MAJIC R&D Center, 331 Pangyo-ro, Seongnam 13488, Gyeonggi, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 Sep 28; Vol. 16 (19). Date of Electronic Publication: 2024 Sep 28.
DOI:	10.3390/nu16193297
Abstrakt:	Background/objectives: Hormonal alterations during menopause result in substantial physiological changes. Although hormone replacement therapy (HRT) is widely used as a treatment strategy for these changes, its use remains controversial due to its associated risks. Plant isoflavones are phytoestrogens that are considered a potential alternative therapy for postmenopausal syndrome. We aimed to investigate the efficacy of ethanolic extracts from Styphnolobium japonicum fruit (SJF) and germinated soybean embryo (GSE) in alleviating prominent menopausal symptoms. Methods: A cell model (MCF7 human breast cancer cells) was used to investigate estrogen-like activity. A rat ovariectomy model was used to simulate estrogen depletion after menopause and to evaluate the efficacy of the SJF-GSE complex extract at ratios of 1:1, 1:2, and 2:1. Results: Treatment with the SJF-GSE extract elicited estrogen-like effects, raising pS2 and estrogen receptor α expression in MCF7 cells. The extract was found to contain 48-72 mg/g sophoricoside and 8-12 mg/g soyasaponin 1, identified as active compounds. In ovariectomized rats, the extract effectively reduced body weight and fat content, alleviated vasomotor symptoms, improved vaginal mucosal health, and exerted osteoprotective effects by enhancing bone density and structure, reducing bone-resorption markers and positively altering estradiol levels and lipid profiles. Conclusions: The SJF-GSE extract, working synergistically, provides a safe and effective alternative to HRT for managing postmenopausal symptoms and enhancing bone health, without adverse effects. These findings support the inclusion of SJF and GSE in health-functional foods and underscore the importance of further research into plant-based therapies for menopause.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu