Very pronounced bowel sparing during radiation therapy for anal carcinoma using a natural spacer (Myoma) - a case report.

Autor: Hoeng L; Department of Radiation Oncology, Justus-Liebig-University Giessen, Giessen-Marburg University Hospital, Giessen, Germany. laura.hoeng@uk-gm.de., Exeli AK; Medical Physics, Department of Radiation Oncology, Giessen-Marburg University Hospital, Giessen, Germany., Krombach GA; Department of Diagnostic and Interventional Radiology, Justus-Liebig-University Giessen, Giessen-Marburg University Hospital, Giessen, Germany., Schwandner T; Department of General and Visceral Surgery, Asklepios Hospital Lich, Lich, Germany., Agolli L; Department of Radiation Oncology, Justus-Liebig-University Giessen, Giessen-Marburg University Hospital, Giessen, Germany., Habermehl D; Department of Radiation Oncology, Justus-Liebig-University Giessen, Giessen-Marburg University Hospital, Giessen, Germany.
Jazyk: angličtina
Zdroj: Radiation oncology (London, England) [Radiat Oncol] 2024 Oct 15; Vol. 19 (1), pp. 145. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1186/s13014-024-02530-6
Abstrakt: Background: Using dose-painted intensity-modulated radiation therapy, specific dose volume constraints or implantation of tissue expanders prior to radiotherapy are validated options for reducing radiation dose on the bowel and therefore minimizing acute gastrointestinal toxicity during chemoradiation for anorectal malignancies. We describe the rare case of a female patient with a locally advanced anal carcinoma where a large myomatous uterus served as a natural spacer to protect the bowel during radiation therapy.
Case Presentation: Initially the patient presented with anal pain, proctoscopy followed by an excisional biopsy confirmed the diagnosis of a squamous cell carcinoma of the anus. Imaging examination showed a locally advanced tumor and in addition a large uterus with typical leiomyomas up to 11.5 cm in diameter. The patient underwent chemoradiation; because of the large leiomyomas there was almost no dose burden for the small intestine and therefore practically no gastrointestinal toxicity.
Conclusion: As we know, this report describes the situation that a large myomatous uterus served as a natural spacer during radiation therapy in a way that is unique to date.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: