Synthesis and characterization of aniline-based azo molecules: In vitro pharmacological and emission studies.

Autor: Shakuntala RB; Department of Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shivmogga, Karnataka, India., Keshavayya J; Department of Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shivmogga, Karnataka, India., Mussuvir Pasha KM; Department of Chemistry, Vijayanagara Sri Krishnadevaraya University, Ballary, Karnataka, India., Pampapathi S; Department of Chemistry, Davanagere University, Shivagangotri, Tolhunase, Davanagere, Karnataka, India.
Jazyk: angličtina
Zdroj: Luminescence : the journal of biological and chemical luminescence [Luminescence] 2024 Oct; Vol. 39 (10), pp. e4904.
DOI: 10.1002/bio.4904
Abstrakt: The present work involves the synthesis of novel dispersed mono-azo dyes using different coupling components and 2-methoxy-5-nitro aniline as amine through a simple and convenient diazo-coupling method. The structures of the newly synthesized mono azo dyes were confirmed by using various spectral techniques such as 1 H NMR, Fourier transform infrared, and high-resolution mass spectrometry. At room temperature, the electronic absorption spectra and fluorescence spectra of the synthesized mono azo dyes were recorded with different solvents. The global reactive parameters for the synthesized azo molecules were evaluated by performing density functional theory through the 6-311++G (d, p) basis set. The anti-microbial activities for the synthesized azo compounds were carried out, and the compounds G1 and G2 exhibited good antibacterial and anti-fungal activities. The in silico molecular docking studies of the azo molecules revealed that all the compounds exhibited extraordinary binding affinity as that of the standard drug. Further, the anti-tuberculosis study against the Mycobacterium tuberculosis for the synthesized azo dyes was evaluated, and from the results, it was revealed that the compound G4 showed good sensitivity among the other synthesized azo compounds.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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