Correlation between lncRNAs with human molecular chaperons in cancer immunopathogenesis and drug resistance.

Autor: Hsu CY; Thunderbird School of Global Management, Arizona State University Tempe Campus, Phoenix, AZ 85004, USA. Electronic address: t545316@gmail.com., Hisham Ateya N; Biotechnology Department, College of Applied Science, Fallujah University, Iraq. Electronic address: 94h.nabaa@gmail.com., Felix Oghenemaro E; Delta State University, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Abraka, Delta State, Nigeria. Electronic address: felixenwa@delsu.edu.ng., Nathiya D; Department of Pharmacy Practice, Institute of Pharmacy, NIMS University Rajasthan, Jaipur, India. Electronic address: dnathiya@nimsuniversity.org., Kaur P; Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali 140307, Punjab, India. Electronic address: parjinder2312.research@cgcjhanjeri.in., Hjazi A; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia. Electronic address: a.hijazi@psau.edu.sa., Eldesoqui M; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Diriyah, 13713, Riyadh, Saudi Arabia. Electronic address: mamrah@um.edu.sa., Yumashev A; Department of Prosthetic Dentistry, Doctor of Medicine, Professor. Sechenov First Moscow State Medical University, Russia. Electronic address: umalex99@yandex.ru., Kadhim Abosaoda M; College of Pharmacy, the Islamic University, Najaf, Iraq; College of Pharmacy, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; College of Pharmacy, the Islamic University of Babylon, Babylon, Iraq. Electronic address: muntherabosoda@iunajaf.edu.iq., Adnan Abdulrahman M; Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2024 Dec 25; Vol. 143 (Pt 1), pp. 113309. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1016/j.intimp.2024.113309
Abstrakt: The development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves. Understanding these mechanisms provides valuable insights into innovative approaches for diagnosis and treatment. Targeting the lncRNA-chaperone axis has the potential to strengthen anti-tumor immunity and enhance cancer treatment outcomes. Further research is necessary to uncover specific associations, identify biomarkers, and develop personalized therapies aimed at disrupting this axis, which could potentially revolutionize cancer diagnosis and treatment.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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