Advances in nanoparticle-based therapeutics for ischemic stroke: Enhancing drug delivery and efficacy.

Autor: Ji P; College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China; Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310000, China., Xu Q; College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China., Li J; College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China., Wang Z; College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China., Mao W; College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China., Yan P; Taizhou Second People's Hospital Affiliated to Yangzhou University, Taizhou 225300, China. Electronic address: tzeykjk2024@163.com.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Nov; Vol. 180, pp. 117564. Date of Electronic Publication: 2024 Oct 13.
DOI: 10.1016/j.biopha.2024.117564
Abstrakt: Ischemic stroke, characterized by vascular occlusion, has recently emerged as one of the primary causes of mortality and disability worldwide. Conventional treatment modalities, such as thrombolytic and neuroprotective therapies, face numerous challenges, including limited bioavailability, significant neurotoxicity, suboptimal targeting, short half-life, and poor blood-brain barrier (BBB) penetration. Nanoparticle-based drug delivery systems present distinct advantages, such as small size, enhanced lipophilicity, and modifiability, which can potentially address these limitations. Utilizing nanoparticles for drug delivery in ischemic stroke therapy offers improved drug bioavailability, reduced neurotoxicity, enhanced targeted delivery, prolonged drug half-life, and better dissolution kinetics. This review aims to provide a comprehensive overview of current strategies in preclinical studies for managing or preventing ischemic stroke from a nanomaterial perspective, highlighting the advantages and limitations of each approach.
Competing Interests: Declaration of Competing Interest The authors declared that they have no conflicts of interest in this study
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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