| Autor: |
Xing Y; Georgia Institute of Technology, Biological Sciences, Atlanta, Georgia, United States., Nho Y; Georgia Institute of Technology, Biological Sciences, Atlanta, Georgia, United States., Lawson K; Georgia Institute of Technology, Atlanta, Georgia, United States., Zhu Y; Georgia Institute of Technology, Atlanta, Georgia, United States., Ellison AE; Georgia Institute of Technology, Atlanta, Georgia, United States., Chang MY; Georgia Institute of Technology, Atlanta, Georgia, United States., Hancock W; Georgia Institute of Technology, Atlanta, Georgia, United States., Han L; Georgia Institute of Technology, Biological Sciences, Atlanta, Georgia, United States; lhan41@gatech.edu. |
| Abstrakt: |
The lung is densely innervated by sensory nerves, the majority of which are derived from the vagal sensory neurons. Vagal ganglia consist of two different ganglia, termed nodose and jugular ganglia, with distinct embryonic origins, innervation patterns, and physiological functions in the periphery. Since nodose neurons constitute the majority of the vagal ganglia, our understanding of the function of jugular nerves in the lung is very limited. This study aims to investigate the role of MrgprC11 + jugular sensory neurons in a mouse allergic asthma model. Our previous study has shown that MrgprC11 + jugular neurons mediate cholinergic bronchoconstriction. In this study, we found that in addition to MrgprC11, several other Mrgpr family members including MrgprA3, MrgprB4, and MrgprD are also specifically expressed in the jugular sensory neurons. MrgprC11 + jugular neurons exhibit dense innervation in the respiratory tract including the larynx, trachea, proximal, and distal bronchus. We also found that receptors for IL-4 and oncostatin M, two critical cytokines promoting allergic airway inflammation, are mainly expressed in jugular sensory neurons. Both IL-4 and oncostatin M can sensitize the neuronal responses of MrgprC11+ jugular neurons. Moreover, ablation of MrgprC11 + neurons significantly inhibited airway hyperresponsiveness in the asthmatic lung, demonstrating the critical role of MrgprC11 + neurons in controlling airway constriction. Our results emphasize the critical role of jugular sensory neurons in respiratory diseases. |
