Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals.

Autor:	Windred DP; Flinders Health and Medical Research Institute (Sleep Health), Flinders University, Bedford Park, SA 5042, Australia.; School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC 3800, Australia., Burns AC; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115.; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114., Lane JM; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115.; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114., Olivier P; Action Lab, Department of Human-Centred Computing, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia., Rutter MK; Centre for Biological Timing, Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, United Kingdom.; Diabetes, Endocrinology and Metabolism Centre, National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester M13 9WU, United Kingdom., Saxena R; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115.; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114., Phillips AJK; Flinders Health and Medical Research Institute (Sleep Health), Flinders University, Bedford Park, SA 5042, Australia.; School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC 3800, Australia., Cain SW; Flinders Health and Medical Research Institute (Sleep Health), Flinders University, Bedford Park, SA 5042, Australia.; School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC 3800, Australia.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 22; Vol. 121 (43), pp. e2405924121. Date of Electronic Publication: 2024 Oct 15.
DOI:	10.1073/pnas.2405924121
Abstrakt:	Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts mortality risk has not been established. We therefore investigated whether personal day and night light, and light patterns that disrupt circadian rhythms, predicted mortality risk. UK Biobank participants (N = 88,905, 62.4 ± 7.8 y, 57% female) wore light sensors for 1 wk. Day and night light exposures were defined by factor analysis of 24-h light profiles. A computational model of the human circadian pacemaker was applied to model circadian amplitude and phase from light data. Cause-specific mortality was recorded in 3,750 participants across a mean (±SD) follow-up period of 8.0 ± 1.0 y. Individuals with brighter day light had incrementally lower all-cause mortality risk (adjusted-HR ranges: 0.84 to 0.90 [50 to 70th light exposure percentiles], 0.74 to 0.84 [70 to 90th], and 0.66 to 0.83 [90 to 100th]), and those with brighter night light had incrementally higher all-cause mortality risk (aHR ranges: 1.15 to 1.18 [70 to 90th], and 1.21 to 1.34 [90 to 100th]), compared to individuals in darker environments (0 to 50th percentiles). Individuals with lower circadian amplitude (aHR range: 0.90 to 0.96 per SD), earlier circadian phase (aHR range: 1.16 to 1.30), or later circadian phase (aHR range: 1.13 to 1.20) had higher all-cause mortality risks. Day light, night light, and circadian amplitude predicted cardiometabolic mortality, with larger hazard ratios than for mortality by other causes. Findings were robust to adjustment for age, sex, ethnicity, photoperiod, and sociodemographic and lifestyle factors. Minimizing night light, maximizing day light, and keeping regular light-dark patterns that enhance circadian rhythms may promote cardiometabolic health and longevity. Competing Interests: Competing interests statement:S.W.C. has consulted for Dyson. A.J.K.P. and S.W.C. are co-founders and co-directors of Circadian Health Innovations PTY LTD. A.J.K.P. and S.W.C. have received research funding from Versalux and Delos. S.W.C. has received research funding from Beacon Lighting. P.O. co-founded Axivity Ltd, and was a director until 2015.
Databáze:	MEDLINE
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